UNC119B Activateurs
Chemical activators of UNC119B can initiate a cascade of cellular events leading to its activation. Phorbol 12-myristate 13-acetate (PMA) is known to robustly activate protein kinase C (PKC), which plays a pivotal role in phosphorylating a myriad of proteins. When PKC is activated, it can target specific residues on UNC119B, leading to its activation through phosphorylation. Forskolin, another activator, works upstream by activating adenylate cyclase, thereby increasing the levels of cAMP within the cell. Elevated cAMP can activate protein kinase A (PKA), which may then phosphorylate UNC119B, altering its activity. Similarly, isoproterenol binds to beta-adrenergic receptors and triggers a rise in cAMP levels, again leading to PKA activation and potential phosphorylation of UNC119B. The direct cAMP molecule also serves as an activator by binding to PKA, facilitating the same pathway towards the activation of UNC119B.
In parallel, some activators function by modulating intracellular calcium levels. Ionomycin, for example, increases intracellular calcium, which can activate calmodulin-dependent kinases, and these kinases could then phosphorylate UNC119B. Calcium ionophore A23187 also raises intracellular calcium concentrations, offering another route to activate calcium-dependent proteins and potentially UNC119B. Phosphatidylserine serves as a lipid signaling molecule and, through its involvement in cellular signaling pathways, can create a favorable environment for the activation of UNC119B. Another lipid-derived molecule, Arachidonic Acid, can be metabolized into eicosanoids which play significant roles in cellular signaling, possibly providing the means for UNC119B activation. Sphingosine-1-phosphate, through its interaction with G-protein coupled receptors, can initiate downstream signaling events that may lead to UNC119B activation. Diacylglycerol (DAG) operates as a second messenger, primarily activating PKC, which in turn could phosphorylate and thus activate UNC119B. Lastly, platelet-activating factor, by engaging its specific receptor, can trigger a signaling cascade with the potential to activate UNC119B. Each of these activators works through distinct yet interconnected pathways, converging on the activation of UNC119B through direct or indirect phosphorylation events.
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| Nom du produit | CAS # | Ref. Catalogue | Quantité | Prix HT | CITATIONS | Classement |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
La PMA active la protéine kinase C (PKC) qui, à son tour, peut activer l'UNC119B par phosphorylation sur des résidus spécifiques. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
La forskoline active l'adénylate cyclase, augmentant les niveaux d'AMPc, ce qui peut conduire à l'activation de la PKA et à la phosphorylation subséquente de l'UNC119B. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
L'ionomycine augmente les niveaux de calcium intracellulaire, ce qui peut activer la kinase dépendante de la calmoduline, conduisant potentiellement à la phosphorylation et à l'activation de l'UNC119B. | ||||||
L-α-Lecithin, Egg Yolk, Highly Purified | 8002-43-5 | sc-203096 | 250 mg | $78.00 | ||
La phosphatidylsérine est impliquée dans la transduction des signaux et peut activer l'UNC119B en interagissant avec les voies de signalisation lipidiques. | ||||||
Arachidonic Acid (20:4, n-6) | 506-32-1 | sc-200770 sc-200770A sc-200770B | 100 mg 1 g 25 g | $90.00 $235.00 $4243.00 | 9 | |
L'acide arachidonique peut être métabolisé en eicosanoïdes qui sont impliqués dans la transduction du signal, ce qui pourrait conduire à l'activation de l'UNC119B. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
La sphingosine-1-phosphate est une molécule de signalisation lipidique qui peut activer l'UNC119B par le biais de ses interactions avec les récepteurs couplés aux protéines G et les cascades de signalisation en aval. | ||||||
Diethylene glycol | 111-46-6 | sc-214888 sc-214888A sc-214888B | 25 g 1 kg 2.5 kg | $26.00 $56.00 $173.00 | ||
Le DAG est un second messager qui active la protéine kinase C, qui pourrait phosphoryler et activer l'UNC119B. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
L'ionophore calcique A23187 augmente le calcium intracellulaire, ce qui peut activer les protéines kinases dépendantes du calcium, entraînant potentiellement l'activation de l'UNC119B. | ||||||
Adenosine 3′,5′-cyclic monophosphate | 60-92-4 | sc-217584 sc-217584A sc-217584B sc-217584C sc-217584D sc-217584E | 100 mg 250 mg 5 g 10 g 25 g 50 g | $114.00 $175.00 $260.00 $362.00 $617.00 $1127.00 | ||
L'AMPc active la protéine kinase A (PKA), qui peut phosphoryler et activer l'UNC119B. | ||||||
Bradykinin | 58-82-2 | sc-507311 | 5 mg | $110.00 | ||
La bradykinine active les récepteurs couplés à la protéine G, ce qui peut conduire à l'activation de la phospholipase C et à la production de DAG, activant potentiellement l'UNC119B par l'intermédiaire de la PKC. | ||||||