Date published: 2025-10-16

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Diethylene glycol (CAS 111-46-6)

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Alternate Names:
2,2′-Oxydiethanol, 2-Hydroxyethyl ether; Bis(2-hydroxyethyl) ether; Diglycol
Application:
Diethylene glycol is A widely used solvent
CAS Number:
111-46-6
Purity:
99%
Molecular Weight:
106.12
Molecular Formula:
C4H10O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Diethylene glycol (DEG) is a versatile organic compound with various applications. It is formed as a side product during the esterification reaction of terephthalic acid with ethylene glycol. Diethylene glycol readily forms complexes with 3d transition metal cations in the presence of alkaline hydroxide, making it useful in antifreeze and lubricating applications. The oxidative degradation of Diethylene glycol with ozone by a modified Fenton process has been studied. Physically, Diethylene glycol is a colorless liquid that is primarily used in the manufacture of other chemicals. It is denser than water and can be formed as a side product during the ester interchange of dimethyl terephthalate with ethylene glycol or direct esterification of terephthalic acid with ethylene glycol. Diethylene glycol is employed as a comonomer in the synthesis of poly(ethylene terephthalate) (PET) and can undergo oxidation when treated with nitric acid. Its toxicity has been extensively assessed, and studies have investigated its ozonation and modified Fenton oxidation.


Diethylene glycol (CAS 111-46-6) References

  1. Screening method for the rapid detection of diethylene glycol in beer based on chemometrics and portable near-infrared spectroscopy.  |  Fulgêncio, ACC., et al. 2022. Food Chem. 391: 133258. PMID: 35640334
  2. Experimental investigation and modelling of synergistic thermodynamic inhibition of Diethylene Glycol and glycine mixture on CO2 gas hydrates.  |  Rehman, AU., et al. 2022. Chemosphere. 308: 136181. PMID: 36064016
  3. Role of Plasma Membrane Dicarboxylate Transporters in the Uptake and Toxicity of Diglycolic Acid, a Metabolite of Diethylene Glycol, in Human Proximal Tubule Cells.  |  Tobin, JD., et al. 2022. Toxicol Sci. 190: 1-12. PMID: 36087010
  4. Preparation of Chemically Resistant Cellulose Benzoate Hollow Fiber Membrane via Thermally Induced Phase Separation Method.  |  Takao, S., et al. 2022. Membranes (Basel). 12: PMID: 36557106
  5. Carboxylated superparamagnetic Fe3O4 nanoparticles modified with 3-amino propanol and their application in magnetic resonance tumor imaging.  |  Wang, C., et al. 2023. BMC Cancer. 23: 54. PMID: 36647053
  6. On the Behavior of the Ethylene Glycol Components of Polydisperse Polyethylene Glycol PEG200.  |  Hoffmann, MM., et al. 2023. J Phys Chem B. 127: 1178-1196. PMID: 36700884
  7. Dataset for the new insights into methane hydrate inhibition with blends of vinyl lactam polymer and methanol, monoethylene glycol, or diethylene glycol as hybrid inhibitors.  |  Semenov, AP., et al. 2023. Data Brief. 46: 108892. PMID: 36710919
  8. In vivo and in vitro toxicity profile of tetrabutylammonium bromide and alcohol-based deep eutectic solvents.  |  Inayat, S., et al. 2023. Sci Rep. 13: 1777. PMID: 36720927
  9. Lack of efflux of diglycolic acid from proximal tubule cells leads to its accumulation and to toxicity of diethylene glycol.  |  Tobin, JD., et al. 2023. Toxicol Lett. 379: 48-55. PMID: 36958672
  10. Comparing Condensed and Hydrolysable Tannins for Mechanical Foaming of Furanic Foams: Synthesis and Characterization.  |  Eckardt, J., et al. 2023. Molecules. 28: PMID: 36985772
  11. Modelling and simulation of waste tire pyrolysis process for recovery of energy and production of valuable chemicals (BTEX).  |  Cao, Y., et al. 2023. Sci Rep. 13: 6090. PMID: 37055516
  12. Solvothermal synthesis of hair-like carbon nanotubes onto sub-micron-sized spherical metal oxide catalyst cores.  |  Kobiro, K., et al. 2023. RSC Adv. 13: 13809-13818. PMID: 37152562
  13. Effects of NO3-, Cl-, and CH3COO- anions and diethylene glycol on the morphological, structural, antidiabetic, and cell viability properties of CeO2 nanoparticles.  |  Matussin, SN., et al. 2023. RSC Adv. 13: 15421-15436. PMID: 37223416
  14. Poly(3-hydroxybutyrate) (PHB) and Polycaprolactone (PCL) Based Blends for Tissue Engineering and Bone Medical Applications Processed by FDM 3D Printing.  |  Krobot, Š., et al. 2023. Polymers (Basel). 15: PMID: 37242979

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Diethylene glycol, 25 g

sc-214888
25 g
$26.00

Diethylene glycol, 1 kg

sc-214888A
1 kg
$56.00

Diethylene glycol, 2.5 kg

sc-214888B
2.5 kg
$173.00