UNC-5 Activators
**UNC-5 activators** are a class of compounds that enhance the expression or activity of the UNC-5 protein. UNC-5 is a netrin receptor that plays a crucial role in axon guidance and neuronal migration during development. UNC-5 activators can increase the levels of UNC-5 protein, promote its interaction with other proteins, or enhance its activity in axon guidance and neuronal migration.
UNC-5 activators exert their effect by modulating different aspects of UNC-5 biology. Some UNC-5 activators, such as nicotinamide, resveratrol, quercetin, curcumin, and epigallocatechin gallate (EGCG), have been shown to induce UNC-5 expression in C. elegans. Other UNC-5 activators, such as sulforaphane, genistein, apigenin, luteolin, kaempferol, quercetin-3-O-glucoside, and myricetin, have also been shown to induce UNC-5 expression in C. elegans. These compounds may act through various mechanisms, such as activating specific signaling pathways or regulating the expression of genes involved in UNC-5 expression. By modulating UNC-5 expression or activity, UNC-5 activators can influence axon guidance and neuronal migration, which are critical processes for the proper development and function of the nervous system. These compounds have been instrumental in dissecting the molecular mechanisms underlying UNC-5 function and its involvement in axon guidance and neuronal migration.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $44.00 $66.00 $204.00 $831.00 | 6 | |
A precursor of NAD+, which has been shown to induce UNC-5 expression in C. elegans. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
A natural polyphenol that has been shown to induce UNC-5 expression in C. elegans. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
A natural flavonoid that has been shown to induce UNC-5 expression in C. elegans. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
A natural compound found in turmeric that has been shown to induce UNC-5 expression in C. elegans. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
A natural polyphenol found in green tea that has been shown to induce UNC-5 expression in C. elegans. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
A natural compound found in cruciferous vegetables that has been shown to induce UNC-5 expression in C. elegans. | ||||||
Apigenin | 520-36-5 | sc-3529 sc-3529A sc-3529B sc-3529C sc-3529D sc-3529E sc-3529F | 5 mg 100 mg 1 g 5 g 25 g 100 g 1 kg | $33.00 $214.00 $734.00 $1151.00 $2348.00 $3127.00 $5208.00 | 22 | |
A natural flavonoid found in many plants that has been shown to induce UNC-5 expression in C. elegans. | ||||||
Luteolin | 491-70-3 | sc-203119 sc-203119A sc-203119B sc-203119C sc-203119D | 5 mg 50 mg 500 mg 5 g 500 g | $27.00 $51.00 $101.00 $153.00 $1925.00 | 40 | |
A natural flavonoid found in many plants that has been shown to induce UNC-5 expression in C. elegans. | ||||||
Myricetin | 529-44-2 | sc-203147 sc-203147A sc-203147B sc-203147C sc-203147D | 25 mg 100 mg 1 g 25 g 100 g | $97.00 $188.00 $260.00 $510.00 $1022.00 | 3 | |
A natural flavonol found in many plants that has been shown to induce UNC-5 expression in C. elegans. | ||||||