Date published: 2025-10-24

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UL16 binding protein (ULBP) Inibitori

UL16 binding proteins (ULBPs) are a group of stress-induced molecules that play a critical role in immune signaling, particularly in the context of cancer and viral infections. These proteins are recognized by the natural killer group 2, member D (NKG2D) receptor, which is present on natural killer (NK) cells and some T cells. Upon binding to ULBPs, NKG2D triggers an immune response that leads to the activation of NK cells and certain T cells, resulting in the targeted killing of cells expressing these stress-induced ligands. This mechanism is crucial for the immune system's ability to detect and eliminate cells that are stressed, infected, or transformed, such as cancer cells. The expression of ULBPs is typically low on healthy cells but is upregulated in response to cellular stress, infection, or transformation, making them key markers for immune surveillance and response.

UL16 binding protein (ULBP) inhibitors constitute a category of chemical compounds designed to interact with and modulate the activity of ULBPs, a group of stress-induced molecules integral to immune system signaling. These proteins, recognized by the NKG2D receptor on natural killer (NK) cells and some T cells, play a pivotal role in the immune response against cells under stress, such as those infected by viruses or undergoing malignant transformation. ULBP inhibitors are developed with the aim of modulating this interaction, either by directly binding to ULBPs and preventing their recognition by NKG2D, or by influencing the cellular mechanisms that regulate ULBP expression.

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Nome del prodottoCAS #Codice del prodottoQuantitàPrezzoCITAZIONIValutazione

Cyclosporin A

59865-13-3sc-3503
sc-3503-CW
sc-3503A
sc-3503B
sc-3503C
sc-3503D
100 mg
100 mg
500 mg
10 g
25 g
100 g
$62.00
$90.00
$299.00
$475.00
$1015.00
$2099.00
69
(5)

Un immunosoppressore in grado di inibire la calcineurina, influenzando così l'espressione del recettore NKG2D e modulando indirettamente le proteine UL16 (ULBP).

SP600125

129-56-6sc-200635
sc-200635A
10 mg
50 mg
$40.00
$150.00
257
(3)

Un inibitore di JNK che può influenzare le vie dello stress e potenzialmente influire sull'espressione delle proteine UL16 (ULBP).

Tyrphostin B42

133550-30-8sc-3556
5 mg
$26.00
4
(1)

Un inibitore di JAK2 in grado di influenzare la segnalazione delle cellule immunitarie e di influenzare indirettamente l'espressione delle proteine UL16 (ULBP).

PP 2

172889-27-9sc-202769
sc-202769A
1 mg
5 mg
$92.00
$223.00
30
(1)

Un inibitore della Src chinasi in grado di influenzare diverse vie di segnalazione e di conseguenza di influire sui livelli di UL16 binding proteins(ULBP).

Wortmannin

19545-26-7sc-3505
sc-3505A
sc-3505B
1 mg
5 mg
20 mg
$66.00
$219.00
$417.00
97
(3)

Un inibitore di PI3K in grado di influenzare le risposte cellulari allo stress e di conseguenza l'espressione delle UL16 binding proteins (ULBP).

BAY 11-7082

19542-67-7sc-200615B
sc-200615
sc-200615A
5 mg
10 mg
50 mg
$61.00
$83.00
$349.00
155
(1)

Un inibitore di NF-κB che può influenzare la segnalazione delle cellule immunitarie e potenzialmente modulare l'espressione delle proteine UL16 (ULBP).

Dasatinib

302962-49-8sc-358114
sc-358114A
25 mg
1 g
$47.00
$145.00
51
(1)

Inibitore multichinasico in grado di influenzare diverse vie di segnalazione e di conseguenza di modulare i livelli di UL16 binding proteins(ULBP).