UBN-1 Activators
UBN-1 Activators encompass a variety of chemical compounds that influence specific cellular pathways, indirectly enhancing the activity of UBN-1 in chromatin remodeling, DNA repair, and gene regulation. Compounds such as Phorbol 12-myristate 13-acetate (PMA) and Forskolin activate PKC and PKA respectively, leading to the phosphorylation of proteins that may interact with UBN-1, thereby facilitating its role in modifying chromatin structure and function. Similarly, Ionomycin, by increasing intracellular Ca2+ concentrations, activates calcium-dependent enzymes that could lead to the activation of factors interacting with UBN-1, enhancing its role in cellular senescence and DNA repair mechanisms.
Furthermore, epigenetic modulators like Trichostatin A and 5-Azacytidine alter thehistone acetylation and DNA methylation landscapes, respectively, thereby modulating the accessibility of UBN-1 to chromatin and influencing its role in nucleosome assembly and the maintenance of heterochromatin stability. Compounds that inhibit phosphatases, such as Okadaic acid and Calyculin A, sustain the phosphorylation state of proteins, possibly supporting the active state of proteins that work in concert with UBN-1 in chromatin remodeling. Additionally, MG132 prevents proteasomal degradation of proteins, enhancing the stability of factors that cooperate with UBN-1 in preserving genomic integrity.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC), leading to phosphorylation of target proteins. PKC-mediated phosphorylation events can activate downstream factors that enhance UBN-1 function in chromatin remodeling and histone modification processes. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular Ca2+ concentration, activating calcium-dependent enzymes and signaling pathways. Elevated Ca2+ levels can lead to the activation of factors that interact with UBN-1 to promote its role in DNA repair and cellular senescence. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
AICAR activates AMP-activated protein kinase (AMPK), which can lead to the phosphorylation of substrates involved in chromatin dynamics. Phosphorylated substrates may support UBN-1-associated processes like DNA repair and chromatin organization. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases 1 and 2A. Inhibition of these phosphatases can enhance the phosphorylation state of proteins, potentially augmenting UBN-1 function by maintaining proteins in an active state that cooperate with UBN-1 in chromatin remodeling. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000C | 10 µg 100 µg 1 mg | $160.00 $750.00 $3000.00 | 59 | |
Similar to okadaic acid, Calyculin A is also an inhibitor of protein phosphatase 1 and 2A, leading to sustained phosphorylation of proteins. This sustained activation can enhance the activity of UBN-1 in processes such as DNA damage response. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing intracellular cAMP levels and activating PKA. PKA then phosphorylates various substrates that may interact with UBN-1, enhancing its function in chromatin remodeling and gene regulation. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG132 is a proteasome inhibitor that can prevent the degradation of regulatory proteins involved in chromatin structure. Stabilization of these proteins can support UBN-1 function in maintaining genomic stability and histone modification. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate is a short-chain fatty acid that acts as an HDAC inhibitor, leading to an open chromatin state and potentially enhancing the access of UBN-1 to chromatin for its role in nucleosome assembly and DNA repair mechanisms. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that can impact the AKT signaling pathway. Alterations in this pathway can influence the activity of downstream proteins that modulate chromatin architecture, thereby enhancing UBN-1's role in chromatin dynamics. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, which can lead to changes in cellular growth and metabolism. This inhibition may induce a cellular state that enhances UBN-1's involvement in chromatin remodeling and gene expression regulation. | ||||||