Twist Activators
Twist Activators are a class of chemical compounds that have been studied for their ability to modulate the activity of Twist proteins, which are key transcription factors involved in various cellular processes, particularly in embryonic development and cancer progression. These activators are primarily used in laboratory research to gain insights into the regulatory mechanisms of Twist proteins and their impact on cellular functions. Twist proteins belong to the family of basic helix-loop-helix (bHLH) transcription factors and play pivotal roles in embryogenesis, tissue differentiation, and metastasis by influencing gene expression patterns.
One common feature of Twist protein activators is their capacity to influence the expression of Twist proteins at the transcriptional or post-translational levels. These compounds often target signaling pathways or epigenetic modifications that govern Twist gene expression. For instance, histone deacetylase inhibitors such as Trichostatin A (TSA) and Valproic Acid (VPA) are known Twist protein activators that function by altering chromatin structure. By inhibiting histone deacetylases, these chemicals promote a more permissive chromatin environment around Twist gene promoters, thereby facilitating their transcription and leading to increased Twist protein levels. Additionally, other activators like Forskolin stimulate intracellular signaling cascades that converge on Twist-regulating transcription factors, ultimately resulting in Twist protein activation. These compounds serve as invaluable tools in deciphering the complex regulatory networks that govern Twist protein activity, shedding light on their roles in development and disease.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid is a derivative of vitamin A and has been shown to activate Twist proteins in certain cellular contexts. | ||||||
Dimethyl Sulfoxide (DMSO) | 67-68-5 | sc-202581 sc-202581A sc-202581B | 100 ml 500 ml 4 L | $31.00 $117.00 $918.00 | 136 | |
DMSO is often used as a solvent to deliver various compounds into cells. It can facilitate the delivery of other activators or agents that modulate Twist expression. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
TSA is a histone deacetylase inhibitor. By inhibiting histone deacetylases, TSA can alter chromatin structure, making Twist gene promoters more accessible for transcription, which may result in increased Twist protein expression. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Similar to TSA, VPA is a histone deacetylase inhibitor. It can increase acetylation of histones, leading to more relaxed chromatin and potentially promoting Twist gene expression. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $34.00 $74.00 $270.00 $114.00 | 34 | |
NAC is an antioxidant and can modulate cellular redox status. Twist activation may be influenced by NAC's effects on oxidative stress and signaling pathways sensitive to redox changes. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin can increase cyclic AMP (cAMP) levels, which can activate protein kinase A (PKA). PKA-mediated signaling pathways can, in turn, lead to Twist protein activation by phosphorylation of relevant transcription factors. | ||||||
Salicylic acid | 69-72-7 | sc-203374 sc-203374A sc-203374B | 100 g 500 g 1 kg | $47.00 $94.00 $119.00 | 3 | |
Salicylic acid has been reported to influence Twist protein expression in certain studies, potentially through its anti-inflammatory and signaling-modulating properties. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $96.00 $264.00 | 2 | |
Ionomycin can elevate intracellular calcium levels. Calcium signaling pathways may contribute to Twist activation in specific cellular contexts. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein, a phytoestrogen, has been studied for its effects on Twist protein expression in cancer research. It may impact Twist through various signaling pathways. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin, found in turmeric, has been investigated for its potential to modulate Twist protein levels. It may influence Twist expression through anti-inflammatory and antioxidant pathways. | ||||||