TTK_Esk Activators
TTK activators are a diverse array of chemical compounds that indirectly enhance the kinase activity of TTK through various cellular signaling pathways and checkpoint mechanisms. Compounds like Paclitaxel, Nocodazole, and Monastrol function by altering microtubule dynamics or spindle assembly, which in turn activates TTK as part of the spindle assembly checkpoint-a critical surveillance mechanism that ensures accurate chromosome segregation. Stabilization of microtubules by Paclitaxel or their disruption by Nocodazole increases the necessity for TTK function in checkpoint signaling. Monastrol's inhibition of kinesin Eg5 leads to monopolar spindle formation, further demanding TTK's role in checkpoint activation. S-Trityl-L-cysteine and ZM447439 contribute similarly by inhibiting kinesin Eg5 and Aurora kinase, respectively, both of which are conditions that can lead to heightened TTK activity due to checkpoint engagement.
Moreover, the action of inhibitors like BI 2536, Reversine, and Hesperadin provides a context in which TTK activity is elevated due to the inhibition of Plk1 and Aurora kinases, key regulators of mitosis wherein TTK is a central player. The suppression of these kinases triggers a compensatory activation of TTK within the spindle assembly checkpoint. Similarly, MLN8054 and PF-03814735, both Aurora kinase inhibitors, indirectly augment TTK activity by engaging the same checkpoint. These mechanisms, together with ATP's essential role in directly fueling TTK's kinase activity, delineate an intricate network of cellular processes that, when modulated by these activators, ensure the enhancement of TTK's essential function in cell cycle control without the need for upregulation of expression or direct activation of the protein itself.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
ADP | 58-64-0 | sc-507362 | 5 g | $53.00 | ||
ATP is a direct activator of many kinases, including TTK. By providing the phosphate groups necessary for kinase activity, ATP enhances TTK's phosphorylation capabilities, which is essential for its kinase activity and subsequent signaling events. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Paclitaxel stabilizes microtubules and can indirectly enhance TTK activity, as TTK is a spindle assembly checkpoint kinase that is activated in response to microtubule dynamics. Stabilized microtubules can lead to increased TTK activity to facilitate proper chromosome alignment and segregation. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Nocodazole disrupts microtubule polymerization, which indirectly enhances TTK activity by activating the spindle assembly checkpoint. This disruption leads to an environment where TTK's kinase activity is necessary for checkpoint signaling. | ||||||
Monastrol | 254753-54-3 | sc-202710 sc-202710A | 1 mg 5 mg | $120.00 $233.00 | 10 | |
Monastrol is a kinesin Eg5 inhibitor which leads to monopolar spindle formation, thereby activating the spindle checkpoint pathway and indirectly enhancing TTK kinase activity as part of the cellular response to spindle damage. | ||||||
S-Trityl-L-cysteine | 2799-07-7 | sc-202799 sc-202799A | 1 g 5 g | $31.00 $65.00 | 6 | |
This compound is an inhibitor of the mitotic kinesin Eg5 which leads to activation of the spindle assembly checkpoint. TTK activity is enhanced as it is a core component of this checkpoint. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $150.00 $349.00 | 15 | |
ZM447439 is an Aurora kinase inhibitor that can indirectly enhance TTK activity by affecting the mitotic checkpoint. TTK is involved in the regulation of this checkpoint and inhibition of Aurora kinase can thus lead to an increased TTK activity. | ||||||
BI 2536 | 755038-02-9 | sc-364431 sc-364431A | 5 mg 50 mg | $148.00 $515.00 | 8 | |
BI 2536 is a Plk1 inhibitor. Inhibition of Plk1 activates the spindle assembly checkpoint and indirectly enhances TTK activity, as TTK plays a critical role in this checkpoint's function. | ||||||
Reversine | 656820-32-5 | sc-203236 | 5 mg | $217.00 | 13 | |
Reversine is a small molecule inhibitor of Aurora kinases and has been shown to activate the spindle assembly checkpoint. This activation can enhance TTK activity, which is essential for the checkpoint's function. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK). Inhibition of JNK can lead to compensatory effects in cell cycle regulation, potentially enhancing TTK activity as it is a key kinase in the mitotic checkpoint. | ||||||
MLN 8054 | 869363-13-3 | sc-484828 | 5 mg | $398.00 | ||
MLN8054 is an Aurora A kinase inhibitor. Inhibition of Aurora A kinase can lead to activation of the spindle assembly checkpoint, thereby enhancing the activity of TTK as a critical component of this checkpoint. | ||||||