TTC17 Activators
TTC17 Activators are a class of compounds that enhance the functional activity of TTC17 through direct or indirect interactions. They work through various signaling pathways that TTC17 is directly involved in. Forskolin, IBMX, Epinephrine, Glutamate, Adenosine, and Nicotine all work through the cAMP-PKA pathway. They influence the pathway by increasing the intracellular cAMP levels, which leads to the activation of PKA. PKA then phosphorylates TTC17, enhancing its functional activity. This class of compounds illustrates how alteration in cAMP levels can directly influence the functional activity of TTC17.
Other activators like Picrotoxin and Strychnine act by increasing neuronal excitability, which can indirectly enhance TTC17 activity. Capsaicin, another TTC17 activator, binds to the TRPV1 receptor, leading to calcium influx, and indirectly enhances TTC17 activity. Resveratrol and Curcumin act on various signaling pathways, including those involving protein kinases and transcription factors, which can indirectly enhance TTC17 activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is an activator of the enzyme adenylyl cyclase, which increases intracellular cAMP levels. Elevated cAMP levels can activate protein kinase A (PKA), which phosphorylates TTC17, leading to its enhanced functional activity. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX acts as an inhibitor of phosphodiesterase, an enzyme that degrades cAMP. By inhibiting phosphodiesterase, IBMX elevates cAMP levels, leading to the activation of PKA. PKA can phosphorylate TTC17, enhancing its functional activity. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine, upon binding to beta-adrenergic receptors, initiates a cascade that elevates cAMP production. The increased cAMP subsequently activates PKA, which phosphorylates TTC17, resulting in increased functional activity. | ||||||
L-Glutamic Acid | 56-86-0 | sc-394004 sc-394004A | 10 g 100 g | $297.00 $577.00 | ||
Glutamate, a neurotransmitter, binds to metabotropic glutamate receptors, which can elevate cAMP levels. Elevated cAMP levels can lead to PKA activation. PKA, in turn, phosphorylates TTC17, enhancing its functional activity. | ||||||
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $34.00 $48.00 $300.00 $572.00 $1040.00 $2601.00 $4682.00 | 1 | |
Adenosine binds to adenosine receptors, which can increase cAMP levels. The elevated cAMP activates PKA, which phosphorylates TTC17, enhancing its functional activity. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine inhibits adenosine receptors, thereby influencing cAMP levels. The altered cAMP levels can lead to PKA activation, which phosphorylates TTC17, enhancing its functional activity. | ||||||
Picrotoxin | 124-87-8 | sc-202765 sc-202765A sc-202765B | 1 g 5 g 25 g | $67.00 $286.00 $1326.00 | 11 | |
Picrotoxin is a GABA-A receptor antagonist. The inhibition of this receptor increases neuronal excitability, which can indirectly enhance TTC17 activity. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
Capsaicin binds to the TRPV1 receptor, leading to calcium influx. The increased intracellular calcium indirectly enhances TTC17 activity. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol activates sirtuins, which can deacetylate proteins involved in the same pathway as TTC17, indirectly enhancing its activity. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin influences various signaling pathways, including those involving protein kinases and transcription factors, which can indirectly enhance TTC17 activity. | ||||||