TSARG1 Inhibitors
TSARG1 Inhibitors comprise a range of compounds that can modulate the expression or function of the Testis-specific androgen-responsive gene protein 1 (TSARG1). A significant mechanism through which many of these inhibitors operate revolves around their ability to interfere with androgen signaling, given the protein's responsive nature to androgens. For instance, compounds like Bicalutamide, Enzalutamide, and Flutamide act as androgen receptor antagonists or competitors, altering the androgen signaling axis and consequently affecting the expression or function of TSARG1.
Furthermore, many inhibitors target broader cellular signaling pathways that might intersect with androgen-mediated effects. LY294002 and Rapamycin, which act upon the PI3K-Akt and mTOR pathways respectively, might affect a cascade of cellular processes, and in doing so, influence the synthesis or function of TSARG1. Similarly, inhibitors like PD98059 and U0126, which target the ERK pathway, can reshape the cellular signaling milieu, affecting downstream proteins or genes activated by androgens, including TSARG1.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Bicalutamide | 90357-06-5 | sc-202976 sc-202976A | 100 mg 500 mg | $42.00 $146.00 | 27 | |
An androgen receptor antagonist. By blocking androgen receptors, the expression or function of TSARG1 might be affected given its androgen-responsive nature. | ||||||
Finasteride | 98319-26-7 | sc-203954 | 50 mg | $105.00 | 3 | |
Inhibits 5α-reductase, reducing dihydrotestosterone (DHT) production. This may affect TSARG1 expression as it's responsive to androgens. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Inhibitor of mTOR pathway, possibly affecting protein synthesis including that of TSARG1. | ||||||
MDV3100 | 915087-33-1 | sc-364354 sc-364354A | 5 mg 50 mg | $245.00 $1051.00 | 7 | |
Another androgen receptor antagonist, potentially altering TSARG1 expression due to reduced androgen signaling. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
By inhibiting the ERK pathway, it can affect potential downstream proteins or genes activated by androgens, which might include TSARG1. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
Inhibits the PI3K-Akt pathway which can be involved in androgen signaling, possibly affecting TSARG1's expression or function. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
Inhibits bromodomain proteins and can affect transcriptional regulation, possibly affecting genes like TSARG1. | ||||||
Flutamide | 13311-84-7 | sc-204757 sc-204757A sc-204757D sc-204757B sc-204757C | 1 g 5 g 25 g 500 g 1 kg | $47.00 $156.00 $171.00 $525.00 $941.00 | 4 | |
An androgen receptor competitor, potentially altering androgen signaling and thus TSARG1 expression. | ||||||
Tyrphostin B42 | 133550-30-8 | sc-3556 | 5 mg | $26.00 | 4 | |
Inhibits the JAK-STAT pathway, which may have intersections with androgen-responsive genes or pathways, affecting TSARG1 indirectly. | ||||||
Spironolactone | 52-01-7 | sc-204294 | 50 mg | $109.00 | 3 | |
An aldosterone antagonist with anti-androgenic properties, potentially affecting TSARG1's androgen responsiveness. | ||||||