MDV3100 (CAS 915087-33-1)

Usage :

MDV3100 is supplied as a crystalline solid. A stock solution may be made by dissolving the MDV3100 in the solvent of choice. MDV3100 is soluble in organic solvents such as ethanol (0.5 mg/ml), DMSO (20 mg/ml), and dimethyl formamide (DMF, 25 mg/ml), which should be purged with an inert gas.


MDV 3100 is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, MDV3100 should first be dissolved in DMF and then diluted with the aqueous buffer of choice. MDV3100 has a solubility of approximately 0.2 mg/ml in a 1:4 solution of DMF:PBS (pH 7.2) using this method. We do not recommend storing the aqueous solution for more than one day.

Appearance :

Powder

Physical State :

Solid

Solubility :

Soluble in methanol, DMSO (93 mg/ml at 25° C), water (<1 mg/ml at 25° C), ethanol (<1 mg/ml at 25° C), and DMF (~25 mg/ml).

Storage :

Store at -20° C

Melting Point :

197-200° C

Boiling Point :

651.93° C (Predicted)

Density :

~1.5 g/cm³ (Predicted)

Refractive Index :

n²⁰_D 1.63 (Predicted)

IC50 :

Androgen Receptor: IC₅₀ = 36 nM; Androgen Receptor: EC₅₀50 = 49 nM (human)

pK Values :

pK_a: 13.88 (Predicted)

PubChem CID :

MDL Number :

MFCD14155804

SMILES :

CC1(C(=O)N(C(=S)N1C2=CC(=C(C=C2)C(=O)NC)F)C3=CC(=C(C=C3)C#N)C(F)(F)F)C