Trp5 Activators
Trp5 Activators are a diverse group of chemical compounds that heighten the functional activity of Trp5 by influencing various biochemical pathways. Forskolin, through the elevation of cAMP, and Sulforaphane, via the NRF2 pathway, indirectly augment Trp5's role in cellular stress responses, as these pathways can lead to the activation of PKA and transcription of protective enzymes, respectively. Curcumin's inhibition of NF-κB and Resveratrol's activation of SIRT1 similarly support the enhancement of Trp5's involvement in stress mechanisms by modulating inflammatory and longevity pathways. Epigallocatechin gallate and Capsaicin further contribute to this enhancement; the former by inhibiting kinases that may suppress Trp5's activity and the latter by initiating calcium influx through TRPV1, which could activate calcium-dependent pathways that include Trp5.
Additionally, compounds like Quercetin and Sodium butyrate indirectly promote Trp5's activity by inhibiting competitive signaling through PI3K and by relaxing chromatin to favor gene regulation, respectively. Hesperidin's facilitation of nitric oxide production and Lithium chloride's inhibition of GSK-3 may both potentiate signaling pathways that indirectly enhance Trp5's function. Omega-3 fatty acids, by altering membrane fluidity, could impact the lipid raft microenvironment and signaling dynamics, indirectly supporting Trp5's activity. Lastly, Zinc sulfate, through its modulation of various enzymatic and transcriptional processes, can indirectly influence signaling cascades, leading to the activation of Trp5, thereby demonstrating how these activators collectively elevate the functional activity of Trp5 without directly upregulating its expression or targeting it for direct activation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin raises intracellular cAMP levels by activating adenylyl cyclase. Increased cAMP can enhance Trp5 activity by activating protein kinase A (PKA), which may phosphorylate and regulate Trp5 or its interacting partners. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane activates the NRF2 pathway, thus enhancing the transcription of protective enzymes. Trp5's activity in stress responses may be indirectly augmented as part of the NRF2-mediated cytoprotective response. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin inhibits NF-κB signaling, potentially reducing inflammation and indirectly enhancing Trp5's role in stress response through a reduction of competing inflammatory pathways. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates SIRT1, which influences stress response pathways. This activation may indirectly heighten Trp5's activity due to improved cellular resilience to stress. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin gallate, by inhibiting certain kinases, may limit inhibitory phosphorylation of proteins that interact with or regulate Trp5, leading to its enhanced activity. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $94.00 $173.00 $255.00 $423.00 | 26 | |
Capsaicin activates TRPV1, leading to calcium influx. This influx can indirectly enhance Trp5 activity by activating calcium-dependent signaling pathways that involve Trp5. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin inhibits PI3K, potentially altering the balance of kinase activity and indirectly enhancing Trp5 activity by reducing competitive signaling. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate inhibits histone deacetylases, potentially favoring gene regulation that enhances the transcription of proteins that regulate or interact with Trp5. | ||||||
Hesperidin | 520-26-3 | sc-205711 sc-205711A | 25 g 100 g | $80.00 $200.00 | 5 | |
Hesperidin increases nitric oxide synthase activity. Elevated nitric oxide can modulate signaling pathways, potentially enhancing Trp5 activity by affecting its regulatory proteins. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits GSK-3, potentially enhancing Wnt signaling and indirectly activating proteins related to Trp5 function, leading to enhanced Trp5 activity. | ||||||