Troponin T Inhibitors
Chemical inhibitors of Troponin T include a variety of calcium channel blockers that impede the calcium-dependent regulatory function of this protein in muscle contraction. Verapamil, Diltiazem, Bepridil, Gallopamil, Mibefradil, Nifedipine, Amlodipine, Nicardipine, and Felodipine are all agents that restrict the influx of calcium ions into cardiac myocytes. By doing so, these chemicals directly limit the amount of calcium available to bind to Troponin T, which is a crucial step for Troponin T to exert its function in the contractile process of muscle fibers. The reduced binding of calcium to Troponin T results in an inhibition of the conformational changes necessary for the activation of actin-myosin cross-bridging, which is essential for muscle contraction. Consequently, Troponin T is unable to participate effectively in the regulation of muscle contraction, leading to its functional inhibition.
In addition to the aforementioned calcium channel blockers, other chemicals like Gadolinium(III) and Ryanodine operate through different mechanisms but ultimately converge on the same pathway of calcium regulation affecting Troponin T function. Gadolinium(III) acts by blocking calcium channels, thus diminishing the pool of calcium ions needed for the activation of Troponin T. Ryanodine interacts with the ryanodine receptor to alter calcium release from the sarcoplasmic reticulum, depleting intracellular calcium stores and thereby decreasing the calcium available for Troponin T function. Tetracaine also contributes to the inhibition of Troponin T by obstructing voltage-gated calcium channels, which leads to a decline in intracellular calcium levels, further inhibiting Troponin T's role in muscle contraction regulation. Collectively, these chemicals execute a targeted inhibition of Troponin T by manipulating the calcium signaling pathways that are vital for its function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Verapamil | 52-53-9 | sc-507373 | 1 g | $367.00 | ||
Verapamil, a calcium channel blocker, can inhibit Troponin T by reducing calcium influx into cardiac myocytes. This leads to a decreased availability of calcium to bind to Troponin T, which is necessary for Troponin T's role in muscle contraction regulation. | ||||||
Diltiazem | 42399-41-7 | sc-204726 sc-204726A | 1 g 5 g | $209.00 $464.00 | 4 | |
Diltiazem functions similarly to Verapamil by blocking calcium channels. The reduced calcium entry into cells decreases the activation of Troponin T, thereby inhibiting its role in cardiac muscle contraction. | ||||||
Bepridil | 64706-54-3 | sc-507400 | 100 mg | $1620.00 | ||
Bepridil, another calcium channel antagonist, inhibits the influx of calcium ions that are essential for Troponin T activation during muscle contraction, thereby functionally inhibiting Troponin T. | ||||||
Gadolinium | 7440-54-2 | sc-250038 | 10 g | $87.00 | ||
Gadolinium(III) ions can block calcium channels, leading to a reduction in calcium ions available to bind to Troponin T and thus inhibiting its function in muscle contraction. | ||||||
Ryanodine | 15662-33-6 | sc-201523 sc-201523A | 1 mg 5 mg | $219.00 $765.00 | 19 | |
Ryanodine locks the ryanodine receptor in an open state, depleting calcium stores from the sarcoplasmic reticulum and reducing the calcium available to activate Troponin T, thereby inhibiting its function. | ||||||
Tetracaine | 94-24-6 | sc-255645 sc-255645A sc-255645B sc-255645C sc-255645D sc-255645E | 5 g 25 g 100 g 500 g 1 kg 5 kg | $66.00 $309.00 $500.00 $1000.00 $1503.00 $5000.00 | ||
Tetracaine blocks voltage-gated calcium channels, decreasing intracellular calcium concentration and thus inhibiting the calcium-dependent function of Troponin T in muscle contraction. | ||||||
Mibefradil dihydrochloride | 116666-63-8 | sc-204083 sc-204083A | 10 mg 50 mg | $209.00 $848.00 | 4 | |
Mibefradil inhibits T-type calcium channels, which can decrease calcium availability for Troponin T activation, thereby inhibiting its role in muscle contraction. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $58.00 $170.00 | 15 | |
Nifedipine is a calcium channel blocker that inhibits the influx of calcium required for Troponin T to regulate muscle contraction, thus functionally inhibiting Troponin T activity. | ||||||
Amlodipine | 88150-42-9 | sc-200195 sc-200195A | 100 mg 1 g | $73.00 $163.00 | 2 | |
Amlodipine selectively inhibits calcium channels, reducing the calcium ion concentration necessary for Troponin T activation and muscle contraction, leading to functional inhibition of Troponin T. | ||||||
Nicardipine hydrochloride | 54527-84-3 | sc-202731 sc-202731A | 1 g 5 g | $32.00 $81.00 | 5 | |
Nicardipine inhibits the influx of calcium ions through L-type calcium channels, which are necessary for the activation of Troponin T in the regulation of muscle contraction, resulting in the functional inhibition of Troponin T. | ||||||