Tropomyosin γ Inhibitors
Tropomyosin γ inhibitors are a class of chemical compounds designed to specifically target and inhibit the function of the tropomyosin γ protein, which is one of the isoforms of the tropomyosin family. Tropomyosins are actin-binding proteins that play a crucial role in the stabilization and regulation of actin filaments, a key component of the cytoskeleton. Tropomyosin γ is involved in modulating the interactions between actin filaments and various actin-associated proteins, thereby influencing the organization, dynamics, and mechanical properties of the actin cytoskeleton. This protein is essential in cellular processes such as cell shape maintenance, motility, and intracellular transport. Inhibitors of tropomyosin γ act by binding to the protein, preventing its association with actin filaments, and thus disrupting its regulatory functions within the cytoskeleton.
Chemically, tropomyosin γ inhibitors are typically small molecules designed to interfere with the actin-binding domains of the tropomyosin γ protein. These inhibitors may block the protein's ability to stabilize actin filaments, resulting in the destabilization of actin structures and impaired cytoskeletal function. Specificity is a key focus in the development of these inhibitors, as other tropomyosin isoforms perform similar but distinct roles within different tissues and cellular contexts. Researchers aim to design inhibitors that selectively target tropomyosin γ without affecting other tropomyosins to avoid widespread disruption of cytoskeletal dynamics. Studying tropomyosin γ inhibitors provides valuable insights into the unique role this isoform plays in actin filament regulation and the broader impact of actin-binding proteins on cellular architecture and mechanical function. These investigations contribute to the understanding of how tropomyosin γ modulates cytoskeletal behavior in processes like cell migration, shape regulation, and intracellular transport.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A, as a histone deacetylase inhibitor, could promote hyperacetylation of histones, leading to altered transcriptional repression mechanisms that may result in decreased expression of Tropomyosin γ. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
By inhibiting DNA methyltransferases, 5-Azacytidine could cause demethylation of the Tropomyosin γ gene promoter, potentially leading to transcriptional silencing and reduced expression of the protein. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
This compound binds to DNA at the transcription initiation complex and prevents elongation of the RNA chain by RNA polymerase, which would result in decreased synthesis of Tropomyosin γ mRNA. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
As an inhibitor of the mTOR pathway, Rapamycin could suppress the initiation of translation process, leading to reduced synthesis of Tropomyosin γ and a subsequent decrease in its cellular levels. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $260.00 $1029.00 | 26 | |
This toxin binds with high affinity to RNA polymerase II, thereby blocking mRNA elongation. This interaction would decrease Tropomyosin γ mRNA synthesis and lower its expression. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Cycloheximide inhibits the translocation step in protein synthesis on eukaryotic ribosomes, resulting in an inhibition of the translation process of Tropomyosin γ, thereby reducing its accumulation. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
By inhibiting the proteasomal degradation pathway, Bortezomib could lead to cellular stress responses that downregulate the transcription of various genes, potentially including those coding for Tropomyosin γ. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
This compound can perturb the endosomal/lysosomal system, which might lead to disruption of mRNA sorting and degradation mechanisms, potentially decreasing the stability and translation of Tropomyosin γ mRNA. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $226.00 $846.00 | 1 | |
JQ1, by inhibiting BET bromodomains, could disrupt the recruitment of transcriptional machinery to specific promoters, possibly leading to a decrease in Tropomyosin γ expression. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Through its role as a ligand for retinoic acid receptors, Retinoic acid can alter gene transcription. It may lead to a downregulation of Tropomyosin γ expression by changing transcription factor binding. | ||||||