Trimethyl Histone H3 Activators
Trimethyl Histone H3 activators are a class of chemicals that modulate the methylation status of histone H3, a protein that plays a crucial role in the structural organization of chromatin in eukaryotic cells. Histone H3 can be post-translationally modified at various lysine residues by the addition of methyl groups, with trimethylation at lysine 4 (H3K4me3), lysine 9 (H3K9me3), or lysine 27 (H3K27me3), among others, having distinct implications for chromatin structure and gene expression.
Chemicals that serve as activators do not directly activate histone H3 in the traditional sense of inducing a conformational change in a protein leading to increased activity. Instead, these molecules typically function by inhibiting the enzymes that remove methyl groups, known as histone demethylases. By preventing the demethylation of histone H3, these activators effectively maintain or increase the level of trimethylation at specific lysine residues. This can lead to changes in chromatin compaction and subsequently influence gene expression by either promoting a more open and transcriptionally active chromatin state or a more condensed and repressive state, depending on the site of methylation. The indirect activators might also increase the expression of histone methyltransferases, the enzymes responsible for adding methyl groups to histone H3, thereby promoting an increase in trimethylation. Alternatively, they may impact the levels of S-adenosylmethionine (SAM), the methyl donor molecule used by methyltransferases, thus affecting the methylation reactions.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate is a histone deacetylase inhibitor. By inhibiting histone deacetylase, it can increase the acetylation level of histones, thereby creating a more relaxed chromatin structure. This can enhance the activity of Trimethyl Histone H3 by increasing its accessibility to the DNA. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor. By increasing the acetylation of histones, it can indirectly enhance the functional activity of Trimethyl Histone H3 by promoting a relaxed chromatin structure and increasing access to DNA. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Valproic acid acts as a histone deacetylase inhibitor. It can enhance the activity of Trimethyl Histone H3 by contributing to a more open chromatin structure, thereby increasing the accessibility of Trimethyl Histone H3 to DNA. | ||||||
Mocetinostat | 726169-73-9 | sc-364539 sc-364539B sc-364539A | 5 mg 10 mg 50 mg | $214.00 $247.00 $1463.00 | 2 | |
Mocetinostat is a histone deacetylase inhibitor that can enhance the activity of Trimethyl Histone H3. By inhibiting histone deacetylase, it promotes a more relaxed chromatin structure, thereby increasing Trimethyl Histone H3's access to DNA. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
SAHA is a histone deacetylase inhibitor. It can enhance the activity of Trimethyl Histone H3 by promoting a more open chromatin structure, thereby increasing the accessibility of Trimethyl Histone H3 to DNA. | ||||||
Panobinostat | 404950-80-7 | sc-208148 | 10 mg | $200.00 | 9 | |
Panobinostat is a histone deacetylase inhibitor that can enhance the activity of Trimethyl Histone H3. By inhibiting histone deacetylase, it promotes a more relaxed chromatin structure, thereby increasing Trimethyl Histone H3's access to DNA. | ||||||
Romidepsin | 128517-07-7 | sc-364603 sc-364603A | 1 mg 5 mg | $218.00 $634.00 | 1 | |
Romidepsin is a histone deacetylase inhibitor. It can enhance the activity of Trimethyl Histone H3 by promoting a more open chromatin structure, thereby increasing the accessibility of Trimethyl Histone H3 to DNA. | ||||||
Belinostat | 414864-00-9 | sc-269851 sc-269851A | 10 mg 100 mg | $156.00 $572.00 | ||
Belinostat is a histone deacetylase inhibitor that can enhance the activity of Trimethyl Histone H3. By inhibiting histone deacetylase, it promotes a more relaxed chromatin structure, thereby increasing Trimethyl Histone H3's access to DNA. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $90.00 $212.00 | 24 | |
Entinostat is a histone deacetylase inhibitor. It can enhance the activity of Trimethyl Histone H3 by promoting a more open chromatin structure, thereby increasing the accessibility of Trimethyl Histone H3 to DNA. | ||||||
ITF2357 | 732302-99-7 | sc-364513 sc-364513A | 5 mg 50 mg | $340.00 $1950.00 | ||
Givinostat is a histone deacetylase inhibitor. It can enhance the activity of Trimethyl Histone H3 by promoting a more open chromatin structure, thereby increasing the accessibility of Trimethyl Histone H3 to DNA. | ||||||