TRIM79 Activators
Chemical activators of TRIM79 can instigate a variety of intracellular signaling pathways leading to its activation. Phorbol 12-myristate 13-acetate (PMA) is one such activator, exerting its effects through the activation of Protein Kinase C (PKC). PKC, once activated, phosphorylates TRIM79, which is a critical step in its activation process. Similarly, forskolin acts through a distinct mechanism, elevating intracellular cyclic AMP (cAMP) levels, which in turn activates Protein Kinase A (PKA). PKA then phosphorylates TRIM79, leading to its activation. Ionomycin, another chemical activator, increases intracellular calcium levels, thereby activating calcium-dependent protein kinases that can phosphorylate and activate TRIM79. Thapsigargin operates by inhibiting the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA), which causes a rise in cytosolic calcium levels. This increase activates calcium-dependent kinases, which then target TRIM79 for activation.
In parallel, Fingolimod initiates the activation of downstream kinases that can phosphorylate TRIM79, while hydrogen peroxide, as a reactive oxygen species, induces oxidative modifications in proteins that activate signaling pathways leading to the phosphorylation of TRIM79. Furthermore, anisomycin, through the activation of stress-activated protein kinases such as JNK, can result in the phosphorylation and subsequent activation of TRIM79. The role of protein phosphatases in the regulation of TRIM79 is highlighted by the action of Calyculin A and Okadaic Acid, both of which inhibit protein phosphatases 1 and 2A, resulting in the sustained phosphorylation and activation of TRIM79. Brefeldin A disrupts Golgi apparatus function, triggering stress signaling pathways that can lead to the phosphorylation of TRIM79 by stress kinases. Lastly, A23187, like ionomycin, facilitates calcium ion influx and activates calcium-dependent kinases, which phosphorylate and activate TRIM79. Bisindolylmaleimide I, while known as a PKC inhibitor, can inadvertently activate alternative signaling pathways that cumulatively result in the activation of TRIM79.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates Protein Kinase C (PKC) which is known to phosphorylate a range of target proteins. Since TRIM79 is a protein that can be regulated by phosphorylation, the activation of PKC by PMA leads to the phosphorylation and consequent activation of TRIM79. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin acts as a calcium ionophore, increasing intracellular calcium levels, which in turn can activate calcium-dependent protein kinases. These kinases can phosphorylate and activate TRIM79. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin inhibits the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA), causing a rise in cytosolic calcium levels. This increase in calcium can activate calcium-dependent kinases that could target and activate TRIM79 through phosphorylation. | ||||||
FTY720 | 162359-56-0 | sc-202161 sc-202161A sc-202161B | 1 mg 5 mg 25 mg | $33.00 $77.00 $120.00 | 14 | |
Fingolimod is a sphingosine-1-phosphate receptor modulator which can lead to the activation of downstream kinases implicated in the phosphorylation and activation of proteins. As a result, kinases activated by Fingolimod could phosphorylate and activate TRIM79. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $31.00 $61.00 $95.00 | 28 | |
Hydrogen Peroxide is a reactive oxygen species that can lead to the oxidative modification of proteins. These modifications can result in the activation of signaling pathways that involve kinases capable of phosphorylating and activating TRIM79. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin activates stress-activated protein kinases (SAPKs) like JNK. Activation of JNK can lead to the phosphorylation of proteins involved in stress response, including TRIM79, leading to its activation. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A inhibits protein phosphatases 1 and 2A, leading to increased phosphorylation of proteins by preventing their dephosphorylation. This inhibition can result in the sustained activation of TRIM79 through phosphorylation. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Similar to Calyculin A, Okadaic Acid is a potent inhibitor of protein phosphatases 1 and 2A, leading to hyperphosphorylation of proteins. This can lead to the activation of TRIM79 through increased phosphorylation. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Brefeldin A disrupts the structure and function of the Golgi apparatus, which can trigger stress signaling pathways. These pathways often result in the activation of molecular chaperones and stress kinases, which could phosphorylate and activate TRIM79. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is a calcium ionophore like ionomycin and facilitates the influx of calcium ions, activating calcium-dependent kinases. These kinases can then phosphorylate and activate TRIM79. | ||||||