TRIM69 Activators
TRIM69 Activators include a range of compounds that indirectly enhance the functional activity of TRIM69, primarily through modulation of protein ubiquitination and degradation pathways. Thalidomide and its derivatives, Lenalidomide and Pomalidomide, exert modulatory effects on the ubiquitin-proteasome system. This modulation potentially enhances TRIM69's role in protein ubiquitination, impacting critical processes such as immune regulation and cell proliferation. Similarly, proteasome inhibitors like MG132 and Bortezomib can influence TRIM69 function by affecting protein degradation pathways, potentially enhancing its involvement in ubiquitin-mediated processes and cellular homeostasis. These interactions underscore TRIM69's pivotal role in protein quality control and degradation mechanisms.
Additionally, natural compounds like Curcumin and Resveratrol modulate TRIM69 activity by influencing cellular signaling pathways involved in stress response and survival, potentially enhancing TRIM69's ubiquitination activity. Chloroquine, affecting lysosomal function and autophagy, and Tunicamycin, impacting N-linked glycosylation, can also influence TRIM69's function in protein degradation, enhancing its role in cellular stress responses. Epoxomicin, as a specific proteasome inhibitor, further impacts TRIM69's activity by targeting ubiquitin-dependent protein degradation. Withaferin A, known for its anti-inflammatory properties, and Prostratin, affecting protein kinase C, can indirectly influence TRIM69's function in protein ubiquitination and signaling pathways. These activators collectively facilitate the enhancement of TRIM69-mediated functions in immune response and cell regulation, highlighting the complex interplay of ubiquitination and proteostasis in which TRIM69 is intricately involved.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Thalidomide | 50-35-1 | sc-201445 sc-201445A | 100 mg 500 mg | $109.00 $350.00 | 8 | |
Thalidomide, through its modulatory effects on the ubiquitin-proteasome pathway, can influence TRIM69's role in protein ubiquitination and degradation, enhancing its regulatory functions in cell signaling and immune responses. | ||||||
Lenalidomide | 191732-72-6 | sc-218656 sc-218656A sc-218656B | 10 mg 100 mg 1 g | $49.00 $367.00 $2030.00 | 18 | |
Lenalidomide, a derivative of thalidomide, affects the ubiquitin-proteasome system. This can indirectly enhance TRIM69's function in protein ubiquitination, impacting immune regulation and cell proliferation. | ||||||
Pomalidomide | 19171-19-8 | sc-364593 sc-364593A sc-364593B sc-364593C sc-364593D sc-364593E | 5 mg 10 mg 50 mg 100 mg 500 mg 1 g | $98.00 $140.00 $306.00 $459.00 $1224.00 $1958.00 | 1 | |
Pomalidomide, another thalidomide analogue, modulates the ubiquitin-proteasome pathway, potentially enhancing TRIM69's activity in protein degradation and immune response mechanisms. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Bortezomib, another proteasome inhibitor, can affect TRIM69's activity in protein ubiquitination and degradation pathways, influencing cellular stress responses and immune regulation. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin, with its broad biological activities, can modulate TRIM69 activity by influencing protein degradation pathways and cellular signaling, enhancing its role in immune responses and cell regulation. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol, a natural polyphenol, can impact TRIM69 function by modulating signaling pathways involved in cell stress response and survival, potentially enhancing its ubiquitination activity. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine, by affecting lysosomal function and autophagy, can influence TRIM69's role in protein degradation, potentially enhancing its activity in cellular stress mechanisms. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $169.00 $299.00 | 66 | |
Tunicamycin, affecting N-linked glycosylation, can influence TRIM69's function in protein quality control and degradation, enhancing its role in cellular stress responses. | ||||||
Epoxomicin | 134381-21-8 | sc-201298C sc-201298 sc-201298A sc-201298B | 50 µg 100 µg 250 µg 500 µg | $134.00 $215.00 $440.00 $496.00 | 19 | |
Epoxomicin, a specific proteasome inhibitor, can impact TRIM69's activity by affecting ubiquitin-dependent protein degradation, influencing immune response and cell regulation. | ||||||
Withaferin A | 5119-48-2 | sc-200381 sc-200381A sc-200381B sc-200381C | 1 mg 10 mg 100 mg 1 g | $127.00 $572.00 $4090.00 $20104.00 | 20 | |
Withaferin A, with its anti-inflammatory properties, can modulate TRIM69 activity, potentially enhancing its role in protein degradation and immune response pathways. | ||||||