TRIM59 Inhibitors
TRIM59 inhibitors belong to a specialized class of chemical compounds designed to target and modulate the activity of TRIM59, which stands for Tripartite Motif Containing 59. TRIM proteins are a large family of proteins characterized by their tripartite motif structure, consisting of a RING domain, a B-box domain, and a coiled-coil domain. These proteins are involved in diverse cellular processes, including protein degradation, innate immunity, and cellular signaling. TRIM59, in particular, is gaining recognition for its roles in various biological processes. Inhibitors of TRIM59 are developed to interact with this specific protein, influencing its interactions with target molecules, its cellular localization, or its enzymatic activities, thereby affecting cellular functions in which TRIM59 participates.
Structurally, TRIM59 inhibitors are designed to engage specific regions or binding sites on the TRIM59 protein. This interaction may interfere with TRIM59's ability to mediate protein-protein interactions or other molecular functions. The precise mechanisms by which TRIM59 inhibitors exert their effects can vary, but their primary aim is to serve as a valuable tool for researchers investigating the roles of TRIM59 in various cellular contexts. Studying the biochemical and functional aspects of TRIM59 and its modulation by inhibitors can contribute to a deeper understanding of cellular processes, intracellular signaling pathways, and the broader field of molecular biology, offering insights into the intricate mechanisms that govern fundamental biological functions.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG132 is a proteasome inhibitor. Since TRIM59 may be involved in protein ubiquitination, MG132 could influence its function by blocking protein degradation. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $226.00 $846.00 | 1 | |
JQ1 is a bromodomain inhibitor affecting gene expression. It might alter TRIM59 expression indirectly through transcriptional regulation. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
As a DNA methyltransferase inhibitor, 5-Azacytidine might modulate TRIM59 gene expression by affecting DNA methylation. | ||||||
Nutlin-3 | 548472-68-0 | sc-45061 sc-45061A sc-45061B | 1 mg 5 mg 25 mg | $56.00 $212.00 $764.00 | 24 | |
Nutlin-3 stabilizes p53 by inhibiting MDM2. Given the role of some TRIM proteins in p53 regulation, this compound might indirectly affect TRIM59. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $96.00 $250.00 $750.00 $1428.00 | 280 | |
Another autophagy inhibitor, it could influence processes related to TRIM59 function. | ||||||
Ruxolitinib | 941678-49-5 | sc-364729 sc-364729A sc-364729A-CW | 5 mg 25 mg 25 mg | $246.00 $490.00 $536.00 | 16 | |
Being a JAK inhibitor, Ruxolitinib might affect inflammatory pathways where TRIM proteins play roles, potentially influencing TRIM59. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
This PI3K inhibitor might affect cellular pathways, including those related to cancer, where TRIM59 is implicated. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
A JNK inhibitor, SP600125 might influence signaling pathways related to TRIM59's function. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
As a ROCK inhibitor, Y-27632 could influence cell migration and proliferation processes related to TRIM59. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $47.00 $145.00 | 51 | |
Dasatinib inhibits several kinases, potentially influencing pathways where TRIM59 operates, especially in a cancer context. | ||||||