TRIM27 Inhibitors
TRIM27 inhibitors encompass a diverse array of chemicals targeting crucial cellular pathways associated with TRIM27 function. Flavopiridol, a CDK inhibitor, disrupts cell cycle progression, indirectly modulating TRIM27 by altering cell cycle-dependent interactions, impacting processes related to cellular proliferation and apoptosis. JQ1, a BET protein inhibitor, disrupts chromatin remodeling, influencing TRIM27 by affecting the accessibility of TRIM27-associated genes, impacting transcriptional regulation and cellular function. MG-132, a proteasome inhibitor, prevents protein degradation, indirectly modulating TRIM27 by stabilizing target proteins and impacting processes related to ubiquitin-proteasome system-mediated degradation and cellular homeostasis. C646, a HAT inhibitor, disrupts histone acetylation, indirectly influencing TRIM27 by altering chromatin accessibility, impacting transcriptional regulation and cellular function. Nutlin-3, a p53-MDM2 interaction inhibitor, disrupts the p53-MDM2 complex, indirectly modulating TRIM27 by affecting p53-mediated transcription and impacting cellular proliferation and apoptosis.
BX795, an inhibitor of TBK1 and IKKε, disrupts the cGAS-STING pathway, indirectly modulating TRIM27 by altering downstream signaling and impacting immune response and inflammation. GSK-J4, a histone demethylase inhibitor, disrupts H3K27me3 demethylation, influencing TRIM27 by altering chromatin accessibility and impacting transcriptional regulation and cellular function. MLN4924, a NAE inhibitor, disrupts cullin neddylation, indirectly modulating TRIM27 by altering the stability of cullin-RING ligases and impacting ubiquitin-proteasome system-mediated degradation and cellular homeostasis. CAY10603, a PKC inhibitor, disrupts PKC signaling pathways, indirectly modulating TRIM27 by altering downstream signaling and impacting cellular proliferation and apoptosis. S3I-201, a STAT3 inhibitor, disrupts STAT3 dimerization and DNA binding, indirectly influencing TRIM27 by affecting downstream events and impacting immune response and inflammation. NSC23766, a Rac1 inhibitor, disrupts Rac1 activation, indirectly modulating TRIM27 by altering downstream events and impacting cellular migration and invasion. BX-795, an inhibitor of TBK1 and IKKε, disrupts the cGAS-STING pathway, indirectly modulating TRIM27 by altering downstream signaling and impacting immune response and inflammation.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Flavopiridol Hydrochloride | 131740-09-5 | sc-207687 | 10 mg | $317.00 | ||
Flavopiridol, a cyclin-dependent kinase (CDK) inhibitor, suppresses CDKs, disrupting cell cycle progression. Its impact on cell cycle modulation indirectly influences TRIM27 by altering cell cycle-dependent interactions, impacting TRIM27-associated processes related to cellular proliferation and apoptosis. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
JQ1, a bromodomain and extraterminal (BET) protein inhibitor, disrupts BET protein binding to acetylated histones. Its influence on chromatin remodeling indirectly modulates TRIM27 by affecting the accessibility of TRIM27-associated genes, impacting processes related to transcriptional regulation and cellular function. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG-132, a proteasome inhibitor, prevents protein degradation. Its action indirectly modulates TRIM27 by stabilizing target proteins, impacting TRIM27-associated processes related to ubiquitin-proteasome system-mediated degradation and cellular homeostasis. | ||||||
C646 | 328968-36-1 | sc-364452 sc-364452A | 10 mg 50 mg | $265.00 $944.00 | 5 | |
C646, a histone acetyltransferase (HAT) inhibitor, disrupts p300/CBP-mediated histone acetylation. Its impact on histone modification indirectly influences TRIM27 by altering chromatin accessibility, impacting TRIM27-associated processes related to transcriptional regulation and cellular function. | ||||||
(–)-Nutlin-3 | 675576-98-4 | sc-222086 sc-222086A | 1 mg 5 mg | $122.00 $219.00 | 2 | |
Nutlin-3, a p53-MDM2 interaction inhibitor, disrupts the p53-MDM2 complex. Its influence on p53 signaling indirectly modulates TRIM27 by affecting p53-mediated transcription, impacting TRIM27-associated processes related to cellular proliferation and apoptosis. | ||||||
BX 795 | 702675-74-9 | sc-281689 sc-281689A sc-281689C sc-281689B sc-281689D sc-281689E | 2 mg 5 mg 10 mg 25 mg 50 mg 100 mg | $219.00 $273.00 $331.00 $495.00 $882.00 $1489.00 | 5 | |
BX795, an inhibitor of TBK1 and IKKε, disrupts the cGAS-STING pathway. Its action indirectly modulates TRIM27 by altering downstream signaling, impacting TRIM27-associated processes related to immune response and inflammation. | ||||||
GSK-J4 | 1373423-53-0 | sc-507551 | 100 mg | $1275.00 | ||
GSK-J4, a histone demethylase (JMJD3/KDM6B) inhibitor, disrupts H3K27me3 demethylation. Its impact on histone modification indirectly influences TRIM27 by altering chromatin accessibility, impacting TRIM27-associated processes related to transcriptional regulation and cellular function. | ||||||
MLN 4924 | 905579-51-3 | sc-484814 | 1 mg | $286.00 | 1 | |
MLN4924, a NEDD8-activating enzyme (NAE) inhibitor, disrupts cullin neddylation. Its influence on the neddylation pathway indirectly modulates TRIM27 by altering the stability of cullin-RING ligases, impacting TRIM27-associated processes related to ubiquitin-proteasome system-mediated degradation and cellular homeostasis. | ||||||
Stat3 Inhibitor VI, S3I-201 | 501919-59-1 | sc-204304 | 10 mg | $151.00 | 104 | |
S3I-201, a STAT3 inhibitor, disrupts STAT3 dimerization and DNA binding. Its impact on STAT3 signaling indirectly influences TRIM27 by affecting downstream events, impacting TRIM27-associated processes related to immune response and inflammation. | ||||||