TRIM12 Inhibitors
TRIM12 inhibitors refer to chemical compounds that target and modulate the activity of the TRIM12 protein, a member of the tripartite motif (TRIM) family. This protein family is characterized by the presence of a RING domain, B-box type 1 and 2 domains, and a coiled-coil region. These structural features are responsible for the protein's involvement in various cellular processes, including ubiquitination, where it plays a role in tagging proteins for degradation. TRIM12 proteins are involved in several biological pathways related to protein homeostasis and immune responses, making them of interest in the study of cellular signaling networks. TRIM12 also exhibits E3 ubiquitin ligase activity, meaning it facilitates the transfer of ubiquitin molecules to substrate proteins, leading to either their degradation by the proteasome or alterations in their cellular function.
Inhibitors of TRIM12 specifically target its enzymatic activity, primarily focusing on interfering with its ability to transfer ubiquitin to substrate proteins. These inhibitors may act by directly binding to the RING domain or other functional sites of TRIM12, thereby preventing the ubiquitin ligase activity and subsequently altering downstream signaling pathways. Such inhibition can have a significant impact on the stability of proteins involved in cell cycle regulation, inflammatory responses, and other key physiological processes. Additionally, the specificity of TRIM12 inhibitors is crucial, as off-target effects on other TRIM proteins or ubiquitin-related enzymes could lead to broader impacts on cellular homeostasis. By targeting TRIM12's enzymatic functions, researchers can gain a deeper understanding of its role in various biochemical pathways and explore the broader implications of ubiquitination in cellular processes.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $226.00 $846.00 | 1 | |
JQ1 may inhibit TRIM12A expression by potentially acting as a competitive inhibitor of the bromodomain, a structural module found in TRIM12A. Inhibition of the bromodomain could interfere with the recruitment of TRIM12A to specific gene loci, ultimately leading to the downregulation of TRIM12A expression. | ||||||
MLN 4924 | 905579-51-3 | sc-484814 | 1 mg | $280.00 | 1 | |
MLN4924 may inhibit TRIM12A expression by potentially acting as an inhibitor of NEDD8-activating enzyme (NAE). Inhibition of NAE could lead to the prevention of the neddylation process, affecting the stability and function of TRIM12A protein, ultimately resulting in the downregulation of TRIM12A expression. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
ATRA (All-trans retinoic acid) may inhibit TRIM12A expression by potentially acting as a modulator of retinoic acid receptor (RAR) signaling. Modulation of RAR activity by ATRA could lead to downstream effects on gene regulation and transcription, ultimately interfering with the expression of TRIM12A. | ||||||
PFI-1 | 1403764-72-6 | sc-478504 | 5 mg | $96.00 | ||
PFI-1 may inhibit TRIM12A expression by potentially acting as a selective inhibitor of the bromodomain, a structural module found in TRIM12A. Inhibition of the bromodomain could interfere with the recruitment of TRIM12A to specific gene loci, ultimately leading to the downregulation of TRIM12A expression. | ||||||
NSC697923 | 343351-67-7 | sc-391107 sc-391107A | 1 mg 5 mg | $15.00 $51.00 | 3 | |
NSC697923 may inhibit TRIM12A expression by potentially acting as a modulator of histone deacetylase (HDAC) activity. Modulation of HDAC activity could lead to alterations in the chromatin structure, ultimately affecting the transcriptional regulation of TRIM12A and resulting in its downregulation. | ||||||
C646 | 328968-36-1 | sc-364452 sc-364452A | 10 mg 50 mg | $260.00 $925.00 | 5 | |
C646 may inhibit TRIM12A expression by potentially acting as a selective inhibitor of the bromodomain, a structural module found in TRIM12A. Inhibition of the bromodomain could interfere with the recruitment of TRIM12A to specific gene loci, ultimately leading to the downregulation of TRIM12A expression. | ||||||
PRT4165 | 31083-55-3 | sc-507487 | 10 mg | $131.00 | ||
PRT4165 may inhibit TRIM12A expression by potentially acting as a modulator of peroxisome proliferator-activated receptor gamma (PPARγ) activity. Modulation of PPARγ activity could lead to downstream effects on gene regulation and transcription, ultimately interfering with the expression of TRIM12A. | ||||||
GSK343 | 1346704-33-3 | sc-397025 sc-397025A | 5 mg 25 mg | $148.00 $452.00 | 1 | |
GSK343 may inhibit TRIM12A expression by potentially acting as a selective inhibitor of the histone lysine methyltransferase EZH2. Inhibition of EZH2 activity could lead to alterations in the chromatin structure, ultimately affecting the transcriptional regulation of TRIM12A and resulting in its downregulation. | ||||||
SGC-CBP30 | 1613695-14-9 | sc-473871 sc-473871A | 5 mg 10 mg | $178.00 $338.00 | ||
SGC-CBP30 may inhibit TRIM12A expression by potentially acting as a selective inhibitor of the bromodomain, a structural module found in TRIM12A. Inhibition of the bromodomain could interfere with the recruitment of TRIM12A to specific gene loci, ultimately leading to the downregulation of TRIM12A expression. | ||||||
UNC1999 | 1431612-23-5 | sc-475314 | 5 mg | $142.00 | 1 | |
UNC1999 may inhibit TRIM12A expression by potentially acting as a selective inhibitor of the histone lysine methyltransferase EZH2. Inhibition of EZH2 activity could lead to alterations in the chromatin structure, ultimately affecting the transcriptional regulation of TRIM12A and resulting in its downregulation. | ||||||