TRF2 Inhibitors
The class of TRF2 inhibitors encompasses a diverse range of chemical compounds strategically designed to modulate TRF2 activity either directly or indirectly through intricate cellular pathways. These inhibitors play crucial roles in influencing cellular processes governed by TRF2-regulated telomere integrity, providing valuable tools for dissecting and manipulating telomere dynamics. BIBR 1532 is a direct inhibitor of TRF2, disrupting its telomere binding activity and interfering with TRF2-mediated telomere protection. MST-312 serves as an indirect inhibitor by modulating telomerase activity, influencing telomere length maintenance and indirectly affecting TRF2. NSC 15520 is a direct inhibitor that interferes with TRF2's telomere binding activity. 6-Thio-dG is an indirect inhibitor that influences telomerase activity, altering telomere dynamics and impacting cellular processes regulated by TRF2-mediated telomere integrity. GSK 3 Inhibitor IX is an indirect inhibitor that modulates the Wnt/β-catenin pathway, influencing TRF2 expression and activity. CEP-3891 is a direct inhibitor that disrupts TRF2's telomere binding activity.
SIRT1 Inhibitor III is an indirect inhibitor that modulates the SIRT1 pathway, impacting TRF2 deacetylation and influencing TRF2 function. AZD 6738 is an indirect inhibitor that modulates the ATM/ATR pathway, influencing TRF2 phosphorylation and impacting TRF2 function. ETP-46464 is a direct inhibitor that interferes with TRF2's telomere binding activity. INK-128 is an indirect inhibitor that modulates the mTOR pathway, impacting TRF2 through mTOR-dependent mechanisms. AZD-7762 is an indirect inhibitor that modulates the CHK1/CHK2 pathway, influencing TRF2 phosphorylation and impacting TRF2 function. In summary, the TRF2 inhibitor class provides a sophisticated toolkit for studying and manipulating telomere dynamics, offering insights into the intricate regulatory mechanisms governing cellular processes influenced by TRF2-mediated telomere integrity.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
BIBR 1532 | 321674-73-1 | sc-203843 sc-203843A | 10 mg 50 mg | $189.00 $748.00 | 6 | |
BIBR 1532 is a direct inhibitor of TRF2, specifically targeting its telomere binding activity. This small molecule interferes with TRF2-mediated telomere protection, directly influencing telomere structure and function. BIBR 1532-induced inhibition disrupts TRF2's role in telomere maintenance, impacting cellular processes governed by TRF2-regulated telomere integrity. | ||||||
Telomerase Inhibitor IX | 368449-04-1 | sc-204333 | 10 mg | $200.00 | 2 | |
MST-312 serves as an indirect inhibitor of TRF2 by modulating telomerase activity. This anthraquinone derivative inhibits telomerase, impacting telomere length maintenance. MST-312-induced inhibition influences TRF2 function by altering telomere dynamics, affecting cellular processes regulated by TRF2-mediated telomere integrity. | ||||||
2′-Deoxy-6-thio Guanosine | 789-61-7 | sc-500420 | 10 mg | $380.00 | ||
6-Thio-dG is an indirect inhibitor of TRF2 by influencing telomerase activity. This modified nucleoside analog selectively inhibits telomerase, impacting telomere length maintenance. 6-Thio-dG-induced inhibition influences TRF2 function by altering telomere dynamics, affecting cellular processes regulated by TRF2-mediated telomere integrity. | ||||||
GSK-3 Inhibitor IX | 667463-62-9 | sc-202634 sc-202634A sc-202634B | 1 mg 10 mg 50 mg | $58.00 $188.00 $884.00 | 10 | |
GSK 3 Inhibitor IX is an indirect inhibitor of TRF2 by modulating the Wnt/β-catenin pathway. This small molecule inhibits GSK-3, leading to β-catenin stabilization. Altered Wnt signaling influences TRF2 expression and activity, impacting cellular processes regulated by TRF2-mediated telomere integrity. | ||||||
EX 527 | 49843-98-3 | sc-203044 | 5 mg | $87.00 | 32 | |
SIRT1 Inhibitor III is an indirect inhibitor of TRF2 by modulating the SIRT1 pathway. This small molecule inhibits SIRT1, impacting TRF2 deacetylation. Altered SIRT1 activity influences TRF2 function, impacting cellular processes regulated by TRF2-mediated telomere integrity. | ||||||
Ceralasertib | 1352226-88-0 | sc-507439 | 10 mg | $573.00 | ||
AZD 6738 is an indirect inhibitor of TRF2 by modulating the ATM/ATR pathway. This small molecule inhibits both ATM and ATR, influencing TRF2 phosphorylation. Altered ATM/ATR signaling influences TRF2 function, impacting cellular processes regulated by TRF2-mediated telomere integrity. | ||||||
ETP-46464 | 1345675-02-6 | sc-497432 | 10 mg | $550.00 | ||
ETP-46464 is a direct inhibitor of TRF2, specifically targeting its telomere binding activity. This small molecule interferes with TRF2-mediated telomere protection, directly influencing telomere structure and function. ETP-46464-induced inhibition disrupts TRF2's role in telomere maintenance, impacting cellular processes governed by TRF2-regulated telomere integrity. | ||||||
INK 128 | 1224844-38-5 | sc-364511 sc-364511A | 5 mg 50 mg | $321.00 $1835.00 | ||
INK-128 is an indirect inhibitor of TRF2 by modulating the mTOR pathway. This small molecule inhibits mTOR, impacting TRF2 through mTOR-dependent mechanisms. Altered mTOR signaling influences TRF2 function, impacting cellular processes regulated by TRF2-mediated telomere integrity. | ||||||
AZD7762 | 860352-01-8 | sc-364423 | 2 mg | $107.00 | ||
AZD-7762 is an indirect inhibitor of TRF2 by modulating the CHK1/CHK2 pathway. This small molecule inhibits CHK1/CHK2, influencing TRF2 phosphorylation. Altered CHK1/CHK2 signaling influences TRF2 function, impacting cellular processes regulated by TRF2-mediated telomere integrity. | ||||||