TRF2 Activators
TRF2, a pivotal component in telomere maintenance, is intricately regulated by a diverse array of compounds classified as TRF2 activators. Telomere-binding compounds, such as BRACO-19 and Telomestatin, directly interact with telomeric DNA, disrupting the TRF2-telomeric DNA complex. This disruption induces telomere destabilization and activates DNA damage responses, positioning these compounds as potential agents for inducing telomere dysfunction with implications in anticancer strategies. G-quadruplex stabilizers like MST-312 and RHPS4 directly interact with telomeric G-quadruplex structures, impacting TRF2 binding and contributing to telomere destabilization. These compounds shed light on the intricate relationship between telomeric DNA structures and TRF2 function, serving as valuable tools for studying telomere dynamics.
Indirect modulators, exemplified by Rhodanine and Piperlongumine, influence TRF2 through distinct pathways. Rhodanine inhibits poly (ADP-ribose) polymerase (PARP), preventing PARP-dependent TRF2 degradation and reinforcing TRF2's role in telomere protection. Piperlongumine induces reactive oxygen species (ROS) production, activating ATM kinase and promoting TRF2 phosphorylation, establishing a link between TRF2 and DNA damage responses. Telomerase inhibitors, including NSC 15520, indirectly impact TRF2 by promoting telomere shortening, thereby enhancing TRF2 binding. This underscores the intricate connection between telomerase activity, telomere length, and TRF2 function in telomere protection. Compounds like Tenovin-6 and Ginkgolic Acid indirectly influence TRF2 by modulating p53 and inhibiting PARP, respectively. These compounds promote TRF2 degradation, emphasizing the cross-talk between TRF2, DNA damage responses, and cellular stress pathways. The diverse mechanisms of action exhibited by these TRF2 activators collectively provide a rich toolkit for dissecting the complex regulatory mechanisms governing telomere maintenance and genomic stability. This nuanced understanding is essential for unraveling the intricacies of telomere biology and may have implications for the development of targeted approaches in various scientific contexts.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rhodanine | 141-84-4 | sc-250897 | 25 g | $45.00 | ||
Rhodanine indirectly influences TRF2 by modulating DNA damage response. It inhibits poly (ADP-ribose) polymerase (PARP), preventing PARP-dependent TRF2 degradation. This indirect activation of TRF2 supports its role in telomere maintenance and genomic stability by regulating the DNA damage response. | ||||||
Piperlongumine | 20069-09-4 | sc-364128 | 10 mg | $107.00 | ||
Piperlongumine indirectly influences TRF2 by inducing reactive oxygen species (ROS) production. ROS activate ATM kinase, leading to TRF2 phosphorylation and increased TRF2 binding to telomeres. This indirect activation supports TRF2's role in the DNA damage response, contributing to telomere maintenance and genomic stability. | ||||||
Ginkgolic acid C17:1 | 111047-30-4 | sc-228252 sc-228252A sc-228252B | 5 mg 10 mg 20 mg | $285.00 $461.00 $851.00 | 2 | |
Ginkgolic Acid indirectly influences TRF2 by inhibiting poly (ADP-ribose) polymerase (PARP), preventing PARP-dependent TRF2 degradation. This indirect activation supports TRF2's role in telomere protection and genomic stability by regulating the DNA damage response and preventing premature telomere shortening. | ||||||
Tenovin-6 | 1011557-82-6 | sc-224296 sc-224296A | 1 mg 5 mg | $272.00 $1214.00 | 9 | |
Tenovin-6 indirectly influences TRF2 by activating p53. It inhibits Sirtuin 1 (SIRT1), leading to p53 acetylation and increased expression. Activated p53 enhances TRF2 degradation, influencing telomere protection and genomic stability. Tenovin-6's indirect action on TRF2 supports its potential as an anticancer agent by promoting DNA damage responses and telomere dysfunction. | ||||||
4-Nitroquinoline N-oxide | 56-57-5 | sc-256815 sc-256815A | 1 g 5 g | $124.00 $421.00 | 6 | |
4-Nitroquinoline 1-Oxide indirectly influences TRF2 by inducing DNA damage. It forms DNA adducts and promotes telomeric DNA breaks, activating ATM kinase and leading to TRF2 phosphorylation. This indirect activation supports TRF2's role in the DNA damage response, contributing to telomere maintenance and genomic stability by regulating telomeric DNA integrity. | ||||||