TRF1 Activators
TRF1 (Telomeric Repeat-binding Factor 1) activators belong to a subset of molecules that primarily influence the activity and functionality of the TRF1 protein. The TRF1 protein is an essential component of the shelterin complex, a protein ensemble that binds and safeguards the ends of chromosomes known as telomeres. Proper functioning and protection of telomeres are crucial for maintaining genomic stability and preventing unwanted telomere fusion events that can contribute to genomic instability. TRF1 plays a key role in ensuring that telomeres are suitably capped and free from adverse recombination processes. Any aberration in its function can lead to complications in the telomeric structure and, subsequently, in cellular function.
Activators of TRF1 function to enhance or modulate the natural activity of the TRF1 protein. The mechanisms by which these activators operate may vary, but common underlying principles often involve direct interactions with the protein, facilitating its binding to telomeres, or by influencing pathways that modulate TRF1's post-translational modifications, stability, or expression levels. The chemical structures of these activators can range widely, and their specificity to TRF1 is of paramount importance to avoid unintended interactions with other proteins or cellular pathways. Research into TRF1 activators often focuses on understanding their precise mode of action, potential off-target effects, and, importantly, their impacts on cellular physiology, especially in the context of telomere biology.
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol, a polyphenol found in grapes and red wine, has been shown to activate sirtuins, proteins that play a role in DNA repair and telomere maintenance. This may indirectly increase TRF1 expression. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin, the main active ingredient in turmeric, is known for its antioxidant properties. It might help in the stabilization of telomeres and may enhance TRF1 expression through anti-inflammatory pathways. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin, a flavonoid found in many plants, might increase TRF1 expression due to its antioxidative properties which can influence telomere maintenance mechanisms. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG, abundant in green tea, can protect telomeres from damage. This protective effect might stimulate the expression of telomere-binding proteins like TRF1. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein, an isoflavone from soy, has been studied for its role in DNA protection. Its potential influence on DNA integrity might affect TRF1 expression. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $90.00 | 1 | |
Berberine, found in several plants, has shown potential to affect telomere length and function, which may indirectly modulate TRF1 expression. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid, a metabolite of vitamin A, can modulate cell differentiation and proliferation. Changes in cell dynamics might influence TRF1 expression and telomere maintenance. | ||||||
Folic Acid | 59-30-3 | sc-204758 | 10 g | $72.00 | 2 | |
Folic acid plays a role in DNA synthesis and repair. Proper DNA maintenance may require increased TRF1 expression. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc is vital for many DNA repair enzymes. Ensuring DNA integrity might stimulate the cellular mechanisms to enhance TRF1 expression. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $33.00 $73.00 $265.00 $112.00 | 34 | |
N-acetylcysteine, an antioxidant, can protect cells from oxidative stress, potentially influencing the cellular pathways that regulate TRF1 expression. | ||||||