TRBP2 Activators
The activation of TRBP2, a key component in the RNA-induced silencing complex (RISC), is crucial for the regulation of gene expression through RNA interference. The proposed activators, ranging from dietary polyphenols like resveratrol and curcumin to biochemical compounds like spermidine and zinc ions, are hypothesized to exert their effects through various molecular mechanisms. These mechanisms include enhancing TRBP2's RNA-binding capabilities, modulating its interaction with other RISC components like Dicer, and influencing its structural stability and phosphorylation status.
These activators may function by stabilizing the RNA-binding domains of TRBP2, thus enhancing its role in gene silencing and post-transcriptional regulation. For instance, EGCG and spermidine might induce conformational changes that improve TRBP2's RNA-binding efficacy. In contrast, compounds like genistein and quercetin could alter TRBP2's interaction dynamics with Dicer, facilitating microRNA processing. Furthermore, agents like S-adenosylmethionine and NMN may impact TRBP2's function by influencing cellular energy states and methylation patterns. The diverse nature of these activators underscores the complexity of TRBP2's regulation and the multiple pathways through which its activity can be activated.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, a polyphenol found in grapes, is hypothesized to activate TRBP2 by enhancing its binding affinity to TAR RNA, potentially influencing RNA interference pathways and thus modulating gene expression. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin, a compound in turmeric, may activate TRBP2 by modulating its phosphorylation status, potentially affecting its interaction with Dicer, a key enzyme in microRNA processing. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG, a major component of green tea, could enhance TRBP2 activity by stabilizing its structure, possibly improving its RNA binding capability, and influencing post-transcriptional gene regulation. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $57.00 $607.00 $176.00 | ||
Spermidine, a polyamine, might activate TRBP2 by inducing conformational changes that enhance its interaction with other components of the RNA-induced silencing complex (RISC), aiding in RNA interference. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein, an isoflavone from soy, could theoretically activate TRBP2 by altering its interaction dynamics with Dicer, potentially enhancing the microRNA maturation process. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin, a flavonoid, might activate TRBP2 by modulating its expression levels, possibly through epigenetic mechanisms, thereby influencing RNA silencing pathways. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc ions could hypothetically enhance TRBP2 activity by stabilizing its RNA-binding domains, thus facilitating its role in the regulation of gene expression via RNA interference. | ||||||
Ademetionine | 29908-03-0 | sc-278677 sc-278677A | 100 mg 1 g | $184.00 $668.00 | 2 | |
Ademetionine could activate TRBP2 by serving as a methyl donor, potentially activating its interaction with RNA and its role in RNA-induced silencing complex assembly. | ||||||
Docosa-4Z,7Z,10Z,13Z,16Z,19Z-hexaenoic Acid (22:6, n-3) | 6217-54-5 | sc-200768 sc-200768A sc-200768B sc-200768C sc-200768D | 100 mg 1 g 10 g 50 g 100 g | $94.00 $210.00 $1779.00 $8021.00 $16657.00 | 11 | |
Activates TRBP2 indirectly by altering cell membrane compositions, which could activate TRBP2's localization and interactions within the cell. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium ions may activate TRBP2 by influencing its phosphorylation state, potentially altering its functional interactions with other RNA-binding proteins and enhancing RNA interference mechanisms. | ||||||