Trav6d-5 Inhibitors
Trav6d-5 inhibitors refer to a class of chemical compounds that specifically target the Trav6d-5 protein or receptor, modulating its biological function. These inhibitors typically function by binding to either the active site or an allosteric site on the Trav6d-5 protein, preventing it from interacting with its natural ligands or substrates. This binding may occur through a variety of non-covalent interactions, including hydrogen bonds, ionic bonds, hydrophobic interactions, and van der Waals forces. The precise nature of these interactions depends on the structure of both the Trav6d-5 protein and the inhibitor itself. Some Trav6d-5 inhibitors are small organic molecules that rely on carefully positioned functional groups to achieve specificity, while others may be larger, more complex molecules with more extensive binding surfaces.
The design of Trav6d-5 inhibitors requires careful consideration of their structural and physicochemical properties. For example, the presence of hydrophilic groups can enhance solubility in aqueous environments, while hydrophobic regions may be necessary for binding to non-polar areas of the Trav6d-5 protein. Additionally, molecular flexibility and size play important roles in determining how well an inhibitor fits into the binding pocket of Trav6d-5. Modifying these features allows for the optimization of binding affinity and selectivity, ensuring that the inhibitor interacts primarily with Trav6d-5 and not with other, similar proteins. Understanding the detailed molecular interactions between Trav6d-5 and its inhibitors is key to determining how these compounds can alter the function of this protein in a controlled and predictable manner.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Azathioprine | 446-86-6 | sc-210853D sc-210853 sc-210853A sc-210853B sc-210853C | 500 mg 1 g 2 g 5 g 10 g | $203.00 $176.00 $349.00 $505.00 $704.00 | 1 | |
Azathioprine may inhibit T cell receptor alpha variable 6D-5 expression by interfering with purine synthesis, leading to reduced proliferation and function of T cells. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $94.00 $213.00 | 33 | |
Methotrexate may inhibit T cell receptor alpha variable 6D-5 expression by inhibiting dihydrofolate reductase, disrupting folate metabolism critical for T cell proliferation. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone may inhibit T cell receptor alpha variable 6D-5 expression by binding to glucocorticoid receptors, suppressing cytokine production and T cell activation. | ||||||
Prednisone | 53-03-2 | sc-205816 sc-205816A sc-205816B | 1 g 5 g 25 g | $42.00 $136.00 $676.00 | 2 | |
Prednisone may inhibit T cell receptor alpha variable 6D-5 expression by suppressing NF-κB activation, leading to reduced transcription of genes involved in T cell activation. | ||||||
Cyclophosphamide | 50-18-0 | sc-361165 sc-361165A sc-361165B sc-361165C | 50 mg 100 mg 500 mg 1 g | $90.00 $146.00 $469.00 $791.00 | 18 | |
Cyclophosphamide may inhibit T cell receptor alpha variable 6D-5 expression by cross-linking DNA, leading to apoptosis of rapidly dividing cells including activated T cells. | ||||||
Leflunomide | 75706-12-6 | sc-202209 sc-202209A | 10 mg 50 mg | $20.00 $83.00 | 5 | |
Leflunomide may inhibit T cell receptor alpha variable 6D-5 expression by inhibiting dihydroorotate dehydrogenase, disrupting de novo pyrimidine synthesis in T cells. | ||||||
Baricitinib | 1187594-09-7 | sc-364730 sc-364730A | 5 mg 25 mg | $200.00 $664.00 | ||
Baricitinib may inhibit T cell receptor alpha variable 6D-5 expression by inhibiting JAK1 and JAK2, leading to suppression of cytokine-mediated T cell activation pathways. | ||||||
Ruxolitinib | 941678-49-5 | sc-364729 sc-364729A sc-364729A-CW | 5 mg 25 mg 25 mg | $251.00 $500.00 $547.00 | 16 | |
Ruxolitinib may inhibit T cell receptor alpha variable 6D-5 expression by inhibiting JAK1 and JAK2, thereby suppressing cytokine signaling crucial for T cell function. | ||||||
Imatinib | 152459-95-5 | sc-267106 sc-267106A sc-267106B | 10 mg 100 mg 1 g | $26.00 $119.00 $213.00 | 27 | |
Imatinib may inhibit T cell receptor alpha variable 6D-5 expression by inhibiting BCR-ABL tyrosine kinase activity, leading to reduced proliferation and activation of T cells. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $70.00 $145.00 | 51 | |
Dasatinib may inhibit T cell receptor alpha variable 6D-5 expression by inhibiting Src family kinases, crucial for T cell receptor signaling and activation of T cells. | ||||||