TRAPPC6B Activators
TRAPPC6B, a subunit of the trafficking protein particle complex, plays a critical role in vesicle trafficking processes within the cell. Activators of TRAPPC6B function by influencing various cellular mechanisms and signaling pathways that are crucial for its role. For instance, compounds that can increase intracellular cAMP levels or calcium ion concentrations can enhance the assembly and function of the trafficking protein particle complex, thereby increasing the activity of TRAPPC6B. Similarly, substances that modulate protein kinase activity, either through direct stimulation or by inhibiting protein phosphatases, can result in the phosphorylation of proteins within the vesicle formation and transport pathways. This phosphorylation cascade ultimately contributes to the regulation of TRAPPC6B activity by affecting the dynamics of vesicle transport and membrane fusion.
Furthermore, certain activators operate by disrupting the structural integrity of the Golgi apparatus or by altering signaling pathways such as PI3K/Akt and MAPK/ERK, which are known to regulate membrane trafficking and dynamics. These disruptions can lead to compensatory cellular responses that involve TRAPPC6B, thereby indirectly augmenting its functional activity. Additionally, analogs of cellular molecules that participate in the activation of GTP-binding proteins, as well as GEFs (guanine nucleotide exchange factors) and GAPs (GTPase-activating proteins), can positively influence TRAPPC6B activity. These proteins are pivotal in the regulation of small GTPases that control vesicle budding, motility, and tethering, processes in which TRAPPC6B is intrinsically involved.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Activates protein kinase C (PKC) which is known to play a role in membrane trafficking by phosphorylating proteins involved in vesicle formation and transport, contributing to the regulation of TRAPPC6B activity in the cell. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Selective calcium ionophore, raising intracellular calcium levels that can influence vesicular transport and secretion pathways that TRAPPC6B participates in, thereby indirectly enhancing its activity in the cell. | ||||||
Adenosine 3′,5′-cyclic Monophosphate, N6-Benzoyl-, Sodium Salt | 30275-80-0 | sc-300167 | 10 µmol | $324.00 | 1 | |
A cAMP analog that activates PKA, leading to phosphorylation of proteins involved in vesicular trafficking, potentially enhancing the function of TRAPPC6B in vesicle transport and membrane fusion. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
A potent inhibitor of protein phosphatases PP1 and PP2A, leading to increased phosphorylation of cellular proteins, which can affect vesicle transport and membrane dynamics, processes that TRAPPC6B is involved in. | ||||||
β-Nicotinamide adenine dinucleotide phosphate | 53-59-8 | sc-215560 sc-215560A | 100 mg 250 mg | $182.00 $319.00 | ||
Functions as a cofactor for NADPH oxidase, which generates reactive oxygen species (ROS) that can modulate vesicular trafficking pathways, potentially increasing the activity of TRAPPC6B in the process. | ||||||
Guanosine 5′-O-(3-thiotriphosphate) tetralithium salt | 94825-44-2 | sc-202639 | 10 mg | $465.00 | ||
A non-hydrolyzable GTP analog that activates GTP-binding proteins involved in vesicular trafficking, which can indirectly stimulate TRAPPC6B activity by promoting vesicle transport processes. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Disrupts the Golgi apparatus structure and function, leading to a blockade in vesicular trafficking and potentially increasing compensatory mechanisms involving TRAPPC6B to maintain cellular homeostasis. | ||||||
Aluminum Fluoride | 7784-18-1 | sc-291881 sc-291881A | 10 g 50 g | $67.00 $250.00 | ||
Acts as a phosphate analog to activate GTPases in their GTP-bound state, which can indirectly influence TRAPPC6B activity by modulating the vesicle trafficking machinery of the cell. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
A specific inhibitor of PI3K, leading to alterations in membrane trafficking and signaling pathways that TRAPPC6B is associated with, thereby potentially influencing its activity in response to disrupted PI3K signaling. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A calcium ionophore that increases intracellular calcium levels, which are crucial for vesicular transport and fusion processes that TRAPPC6B is involved in, indirectly stimulating its functional activity. | ||||||