Date published: 2025-10-16

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TRAP95 Inhibitors

TRAP95 inhibitors represent a distinctive class of chemical compounds that target the TRAP95 protein, also known as Tat-activating regulatory protein of 95 kDa. TRAP95 is a multifunctional protein involved in various cellular processes, particularly in the regulation of transcriptional activities. This protein plays a pivotal role in the assembly of the p400/Tip60 chromatin remodeling complex, which, in turn, modulates the acetylation of histones and contributes to the dynamic regulation of gene expression. The development of TRAP95 inhibitors stems from the recognition of the crucial role this protein plays in cellular functions, particularly in the context of chromatin remodeling.

The chemical structures of TRAP95 inhibitors are designed to interact specifically with the catalytic sites or binding domains of TRAP95, hindering its enzymatic activity or disrupting its interactions with other cellular components. By selectively inhibiting TRAP95, these compounds aim to modulate the intricate network of molecular events governing transcriptional regulation. Researchers are actively exploring the applications of TRAP95 inhibitors in unraveling the complexities of gene expression and understanding the underlying mechanisms of various cellular processes.

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Items 1 to 10 of 11 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Staurosporine

62996-74-1sc-3510
sc-3510A
sc-3510B
100 µg
1 mg
5 mg
$82.00
$150.00
$388.00
113
(4)

A kinase inhibitor that can affect various signaling pathways, potentially altering TRAP95 function.

LY 294002

154447-36-6sc-201426
sc-201426A
5 mg
25 mg
$121.00
$392.00
148
(1)

A PI3K inhibitor that can disrupt downstream signaling, potentially affecting TRAP95 interaction.

SB 203580

152121-47-6sc-3533
sc-3533A
1 mg
5 mg
$88.00
$342.00
284
(5)

A p38 MAPK inhibitor that might modify cytoskeletal dynamics, indirectly impacting TRAP95.

Rapamycin

53123-88-9sc-3504
sc-3504A
sc-3504B
1 mg
5 mg
25 mg
$62.00
$155.00
$320.00
233
(4)

An mTOR inhibitor that can alter cellular growth pathways, potentially affecting TRAP95 levels.

Cycloheximide

66-81-9sc-3508B
sc-3508
sc-3508A
100 mg
1 g
5 g
$40.00
$82.00
$256.00
127
(5)

Inhibits protein synthesis, which can lead to a decrease in TRAP95 expression.

Wortmannin

19545-26-7sc-3505
sc-3505A
sc-3505B
1 mg
5 mg
20 mg
$66.00
$219.00
$417.00
97
(3)

Another PI3K inhibitor that can disrupt cell survival signaling, potentially affecting TRAP95.

SP600125

129-56-6sc-200635
sc-200635A
10 mg
50 mg
$40.00
$150.00
257
(3)

An inhibitor of JNK, which can alter stress response pathways, potentially impacting TRAP95.

Thapsigargin

67526-95-8sc-24017
sc-24017A
1 mg
5 mg
$94.00
$349.00
114
(2)

An ER stress inducer that can lead to signaling changes, potentially influencing TRAP95 levels.

Brefeldin A

20350-15-6sc-200861C
sc-200861
sc-200861A
sc-200861B
1 mg
5 mg
25 mg
100 mg
$30.00
$52.00
$122.00
$367.00
25
(3)

Disrupts protein transport, which can affect TRAP95's role in the cytoskeleton.

PD 98059

167869-21-8sc-3532
sc-3532A
1 mg
5 mg
$39.00
$90.00
212
(2)

An ERK pathway inhibitor that might modulate signaling pathways involving TRAP95.