TRAP95 Antibody (F83): sc-130439

TRAP95 Antibody (F83) is a mouse monoclonal IgG2b kappa light chain antibody that detects TRAP95 protein of human origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). TRAP95 (F83) antibody is available as a non-conjugated anti-TRAP95 antibody. TRAP95 protein plays a crucial role in the regulation of transcription within mammalian cells, functioning as a key component of the thyroid hormone receptor-associated protein (TRAP) complex. This complex is essential for mediating the interaction between transcriptional activators and initiation factors, thereby facilitating hormone-induced transcriptional activation. The TRAP complex is composed of several proteins, including TRAP95, TRAP100, TRAP150, TRAP220, and TRAP230, all of which contain a nuclear receptor recognition motif that enables ligand-dependent binding to nuclear receptors. TRAP95, along with TRAP150 and TRAP230, enhances transcriptional activity by associating with the SMCC (SRB and MED protein cofactor complex), which is integral to the transcriptional machinery. Expression of TRAP proteins, particularly TRAP220 and TRAP100, is most prominent in tissues such as skeletal muscle, heart, and placenta, highlighting their importance in various physiological processes. Anti-TRAP95 antibody (F83) effectively detects TRAP95, making this antibody a valuable tool for researchers studying transcriptional regulation and its implications in health and disease.

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TRAP95 Antibody (F83) References:

1. A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation.  |  Gu, W., et al. 1999. Mol Cell. 3: 97-108. PMID: 10024883
2. Competition between thyroid hormone receptor-associated protein (TRAP) 220 and transcriptional intermediary factor (TIF) 2 for binding to nuclear receptors. Implications for the recruitment of TRAP and p160 coactivator complexes.  |  Treuter, E., et al. 1999. J Biol Chem. 274: 6667-77. PMID: 10037764
3. Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators.  |  Ito, M., et al. 1999. Mol Cell. 3: 361-70. PMID: 10198638
4. Identification of mouse TRAP100: a transcriptional coregulatory factor for thyroid hormone and vitamin D receptors.  |  Zhang, J. and Fondell, JD. 1999. Mol Endocrinol. 13: 1130-40. PMID: 10406464
5. The structure of the nuclear hormone receptors.  |  Kumar, R. and Thompson, EB. 1999. Steroids. 64: 310-9. PMID: 10406480
6. The TRAP220 component of a thyroid hormone receptor- associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion.  |  Yuan, CX., et al. 1998. Proc Natl Acad Sci U S A. 95: 7939-44. PMID: 9653119
7. Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways.  |  Jiang, YW., et al. 1998. Proc Natl Acad Sci U S A. 95: 8538-43. PMID: 9671713

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TRAP95 Antibody (F83) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-TRAP95 Antibody (F83) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TRAP95 Antibody (F83) Specifications

Alternate Product Name: TRAP95

Product Clone Name: F83

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 1-111

Epitope Target: TRAP95

Epitope Species: human

Product Reactivity/Detection: TRAP95

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF

Vialing Information: Each vial contains 100 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for TRAP95 Antibody (F83): N/A