Transketolase Inhibitors
The chemical class known as Transketolase Inhibitors comprises a diverse array of compounds that directly or indirectly interfere with the enzymatic activity of transketolase, a critical player in the pentose phosphate pathway. Oxythiamine, deoxythiamine, and 6-aminonicotinamide act as direct inhibitors by competing with the cofactor thiamine pyrophosphate (TPP) for binding to transketolase, disrupting the non-oxidative branch of the pentose phosphate pathway and impacting cellular processes related to nucleotide biosynthesis. Compounds like alloxan, auranofin, and hydroquinone exert their inhibitory effects by inducing oxidative stress and altering cellular redox status, leading to indirect disruption of the non-oxidative branch of the pentose phosphate pathway. Sodium arsenite acts as an indirect inhibitor by inducing oxidative stress and disturbing redox balance, influencing cellular processes related to nucleotide biosynthesis under conditions of arsenic-induced oxidative stress.
Tungstate and molybdate mimic the structure of TPP, directly inhibiting transketolase by competing for its binding site and disrupting the enzymatic activity. Compounds like tannic acid and acriflavine inhibit transketolase by binding to the enzyme and altering its structure, interfering with the non-oxidative branch of the pentose phosphate pathway and impacting cellular processes related to nucleotide biosynthesis. Quercetin, acting as an indirect inhibitor, modulates cellular redox status and induces oxidative stress, disrupting the non-oxidative branch of the pentose phosphate pathway. Collectively, these compounds exemplify the diverse strategies employed by Transketolase Inhibitors to interfere with cellular processes crucial for nucleotide biosynthesis and other pathways dependent on transketolase function.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Oxythiamine chloride hydrochloride | 614-05-1 | sc-236265 sc-236265A sc-236265B | 1 g 5 g 25 g | $39.00 $119.00 $437.00 | 2 | |
Oxythiamine inhibits transketolase by forming a complex with its cofactor thiamine pyrophosphate (TPP), blocking the enzymatic activity. This direct inhibition disrupts the non-oxidative branch of the pentose phosphate pathway, potentially affecting cellular processes related to nucleotide biosynthesis and other transketolase-dependent pathways. | ||||||
6-Aminonicotinamide | 329-89-5 | sc-278446 sc-278446A | 1 g 5 g | $153.00 $390.00 | 3 | |
6-Aminonicotinamide inhibits transketolase by mimicking the structure of the cofactor TPP and competing for its binding site. This direct inhibition disrupts the enzymatic activity of transketolase, affecting the non-oxidative branch of the pentose phosphate pathway and potentially modulating cellular processes related to nucleotide biosynthesis and other transketolase-dependent pathways. | ||||||
Alloxan monohydrate | 2244-11-3 | sc-254940 | 10 g | $53.00 | ||
Alloxan induces oxidative stress and selectively inhibits transketolase by damaging its cofactor TPP. This direct inhibition disrupts the non-oxidative branch of the pentose phosphate pathway, potentially impacting cellular processes associated with nucleotide biosynthesis and other transketolase-dependent pathways in conditions of oxidative stress. | ||||||
Auranofin | 34031-32-8 | sc-202476 sc-202476A sc-202476B | 25 mg 100 mg 2 g | $150.00 $210.00 $1899.00 | 39 | |
Auranofin inhibits transketolase indirectly by modulating cellular redox status. Through its ability to induce oxidative stress and alter the cellular environment, auranofin can disrupt the non-oxidative branch of the pentose phosphate pathway, potentially influencing cellular processes related to nucleotide biosynthesis and other transketolase-dependent pathways. | ||||||
Hydroquinone | 123-31-9 | sc-204773 sc-204773A sc-204773B | 250 g 1 kg 5 kg | $36.00 $91.00 $392.00 | ||
Hydroquinone inhibits transketolase by interfering with the redox status of the enzyme. Through its oxidative effects, hydroquinone disrupts the non-oxidative branch of the pentose phosphate pathway, potentially affecting cellular processes related to nucleotide biosynthesis and other transketolase-dependent pathways by modulating the enzyme's redox-sensitive activity. | ||||||
Sodium (meta)arsenite | 7784-46-5 | sc-250986 sc-250986A | 100 g 1 kg | $106.00 $765.00 | 3 | |
Sodium arsenite inhibits transketolase by disrupting cellular redox balance and inducing oxidative stress. This indirect inhibition disrupts the non-oxidative branch of the pentose phosphate pathway, potentially impacting cellular processes related to nucleotide biosynthesis and other transketolase-dependent pathways under conditions of arsenic-induced oxidative stress. | ||||||
Gallotannin | 1401-55-4 | sc-202619 sc-202619A sc-202619B sc-202619C sc-202619D sc-202619E sc-202619F | 1 g 10 g 100 g 250 g 1 kg 2.5 kg 5 kg | $25.00 $36.00 $66.00 $76.00 $229.00 $525.00 $964.00 | 12 | |
Gallotannin inhibits transketolase by binding to the enzyme and disrupting its structure. This direct inhibition interferes with the non-oxidative branch of the pentose phosphate pathway, potentially impacting cellular processes related to nucleotide biosynthesis and other transketolase-dependent pathways by altering the structural integrity of the enzyme. | ||||||
Acriflavine | 8048-52-0 | sc-214489 sc-214489A | 25 g 100 g | $49.00 $168.00 | 2 | |
Acriflavine inhibits transketolase by interfering with its cofactor binding. This direct inhibition disrupts the non-oxidative branch of the pentose phosphate pathway, potentially influencing cellular processes related to nucleotide biosynthesis and other transketolase-dependent pathways by preventing the formation of the active enzyme-cofactor complex. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin inhibits transketolase indirectly by modulating cellular redox status and inducing oxidative stress. Through its antioxidant properties, quercetin can disrupt the non-oxidative branch of the pentose phosphate pathway, potentially affecting cellular processes related to nucleotide biosynthesis and other transketolase-dependent pathways by mitigating the oxidative effects on the enzyme. | ||||||