TRAC-1 Activators
Nuclear Receptor Corepressor 2 (NCOR2), also known as Silencing Mediator for Retinoic acid and Thyroid hormone receptors (SMRT), is a crucial protein in the human body encoded by the NCOR2 gene. It plays a significant role in gene expression regulation, acting as a transcriptional corepressor for various nuclear receptors.NCOR2 operates by forming complexes with histone deacetylases (HDACs) and other nuclear receptors. These complexes alter chromatin structure through histone deacetylation, a process that generally represses gene transcription. This allows NCOR2 to modulate the activity of many genes indirectly.
This protein's functionality is not limited to a single role. It interacts with a host of receptors, including thyroid hormone receptors (TRs), retinoic acid receptors (RARs), and peroxisome proliferator-activated receptors (PPARs), thus influencing a broad range of biological processes. These include lipid metabolism, cell differentiation, and circadian rhythms.NCOR2 also has a significant role in embryonic development. It is involved in the process of organogenesis, where it helps regulate the development of organs and tissues. Disruptions in NCOR2 activity can lead to developmental disorders.In the context of disease, aberrant functioning of NCOR2 has been linked to several types of cancer, including breast and prostate cancer. Altered expression of NCOR2 can affect the normal balance of gene activation and repression, leading to abnormal cellular activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol has been shown to upregulate NCoR2 expression. It may potentially enhance the inhibitory effect of NCoR2 on transcription factors. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin has been reported to induce the expression of NCoR2. It may contribute to the regulation of gene expression through NCoR2-mediated transcriptional repression. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin has been suggested to increase NCoR2 expression. It may modulate gene expression by promoting the recruitment of NCoR2 to transcriptional regulatory regions. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein has been shown to upregulate NCoR2 expression. It may participate in the regulation of gene expression through NCoR2-mediated transcriptional repression. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane has been reported to induce the expression of NCoR2. It may contribute to the modulation of gene expression by enhancing NCoR2-mediated transcriptional repression. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG has been suggested to increase NCoR2 expression. It may play a role in the regulation of gene expression through NCoR2-mediated transcriptional repression. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone has been shown to upregulate NCoR2 expression. It may potentially enhance the inhibitory effect of NCoR2 on transcription factors. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid has been reported to induce the expression of NCoR2. It may contribute to the regulation of gene expression through NCoR2-mediated transcriptional repression. | ||||||
Troglitazone | 97322-87-7 | sc-200904 sc-200904B sc-200904A | 5 mg 10 mg 25 mg | $110.00 $204.00 $435.00 | 9 | |
Troglitazone has been suggested to increase NCoR2 expression. It may modulate gene expression by promoting the recruitment of NCoR2 to transcriptional regulatory regions. | ||||||
1α,25-Dihydroxyvitamin D3 | 32222-06-3 | sc-202877B sc-202877A sc-202877C sc-202877D sc-202877 | 50 µg 1 mg 5 mg 10 mg 100 µg | $220.00 $645.00 $1000.00 $1500.00 $440.00 | 32 | |
1,25-Dihydroxyvitamin D3 has been shown to upregulate NCoR2 expression. It may participate in the regulation of gene expression through NCoR2-mediated transcriptional repression. | ||||||