TORC2 Inhibitors
The class of compounds known as TORC2 inhibitors comprises a spectrum of chemicals specifically designed to modulate TORC2 activity through direct interference with mTOR kinase. Torin 1, KU-0063794, PP242, OSI-027, AZD2014, INK128, WYE-687, GSK2141795, AZ20, and Torin 2 are all ATP-competitive mTOR inhibitors that directly target TORC2 by suppressing mTOR kinase activity. By doing so, they disrupt the assembly and function of TORC2, leading to altered phosphorylation patterns of downstream effectors, including AKT.
Rapamycin and Temsirolimus, while not direct TORC2 inhibitors, indirectly influence TORC2 by disrupting mTORC1 signaling. The inhibitory effect on mTORC1 prevents negative feedback on the insulin receptor substrate (IRS) pathway, resulting in enhanced PI3K/AKT signaling and impacting TORC2-mediated processes. These indirect modulators highlight the interconnected nature of mTORC1 and TORC2 signaling pathways. This diverse array of TORC2 inhibitors offers valuable insights into the intricate regulatory mechanisms governing TORC2 activity. Their direct or indirect impact on TORC2-mediated signaling cascades sheds light on strategies for manipulating TORC2 dynamics in a targeted manner. Understanding the detailed biochemical and cellular pathways influenced by these inhibitors is crucial for unraveling the complexity of TORC2 regulation and exploring applications in various cellular contexts.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Torin 1 | 1222998-36-8 | sc-396760 | 10 mg | $245.00 | 7 | |
Torin 1, a potent and selective ATP-competitive inhibitor of mTOR, directly inhibits TORC2 by suppressing the kinase activity of mTOR. The inhibition of mTOR prevents its association with Rictor, a crucial component of TORC2, disrupting the integrity and function of TORC2. | ||||||
KU 0063794 | 938440-64-3 | sc-361219 | 10 mg | $209.00 | ||
KU-0063794, a selective inhibitor of mTOR, directly targets TORC2 by inhibiting mTOR kinase activity. By interfering with mTOR, KU-0063794 disrupts the assembly and function of TORC2. This inhibition results in altered phosphorylation patterns of downstream effectors such as AKT, influencing cellular processes controlled by TORC2. | ||||||
PP242 | 1092351-67-1 | sc-301606A sc-301606 | 1 mg 5 mg | $57.00 $172.00 | 8 | |
PP242, a second-generation mTOR inhibitor, directly inhibits TORC2 by targeting mTOR kinase. The interference with mTOR prevents its interaction with Rictor within TORC2, leading to impaired TORC2 function. PP242's direct inhibition of TORC2 is reflected in the modulation of downstream signaling, impacting cellular responses mediated by TORC2-regulated pathways, including AKT phosphorylation. | ||||||
OSI-027 | 936890-98-1 | sc-364557 sc-364557A | 10 mg 50 mg | $437.00 $1186.00 | 1 | |
OSI-027, an mTOR kinase inhibitor, directly targets TORC2 by disrupting mTOR's kinase activity. The inhibition of mTOR interferes with its association with Rictor within TORC2, impairing TORC2 function. This direct inhibition manifests in altered phosphorylation of downstream effectors like AKT, influencing cellular processes governed by TORC2. | ||||||
AZD2014 | 1009298-59-2 | sc-364420 | 5 mg | $303.00 | 2 | |
AZD2014, an mTOR inhibitor, directly inhibits TORC2 by targeting mTOR kinase. Through interference with mTOR, AZD2014 disrupts the assembly and function of TORC2. This direct inhibition results in altered phosphorylation patterns of downstream effectors, such as AKT, impacting cellular processes controlled by TORC2. | ||||||
INK 128 | 1224844-38-5 | sc-364511 sc-364511A | 5 mg 50 mg | $321.00 $1835.00 | ||
INK128, a dual TORC1/TORC2 inhibitor, directly targets TORC2 by inhibiting mTOR kinase. By interfering with mTOR, INK128 disrupts the assembly and function of TORC2. This direct inhibition leads to altered phosphorylation patterns of downstream effectors, including AKT, influencing cellular processes governed by TORC2. | ||||||
WYE-687 | 1062161-90-3 | sc-364653 sc-364653A | 10 mg 50 mg | $235.00 $992.00 | ||
WYE-687, a dual TORC1/TORC2 inhibitor, directly targets TORC2 by inhibiting mTOR kinase. The interference with mTOR disrupts the assembly and function of TORC2, leading to altered phosphorylation patterns of downstream effectors such as AKT. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin, an allosteric mTOR inhibitor, indirectly influences TORC2 by disrupting mTORC1 signaling. While not a direct TORC2 inhibitor, rapamycin's inhibitory effect on mTORC1 has downstream consequences on TORC2 signaling. The inhibition of mTORC1 prevents negative feedback on the insulin receptor substrate (IRS) pathway, leading to enhanced PI3K/AKT signaling, impacting TORC2-mediated processes. | ||||||
AZ20 | 1233339-22-4 | sc-503186 | 5 mg | $255.00 | 1 | |
AZ20, a dual TORC1/TORC2 inhibitor, directly targets TORC2 by inhibiting mTOR kinase. The interference with mTOR disrupts the assembly and function of TORC2, leading to altered phosphorylation patterns of downstream effectors such as AKT. | ||||||