TMPRSS11F Activators
TMPRSS11F Activators encompass a range of chemical compounds that indirectly bolster the protease's functional capacity by targeting competitive proteolytic pathways or preserving substrate integrity. Benzamidine and Camostat mesylate, both serine protease inhibitors, augment TMPRSS11F by preventing the breakdown of its substrates through the inhibition of other serine proteases, thereby increasing substrate availability. Similarly, Nafamostat mesylate, Gabexate mesylate, and Aprotinin, by reducing the activity of a broad spectrum of competing proteases, indirectly facilitate TMPRSS11F's access to its substrates. Leupeptin, with its ability to inhibit serine and cysteine proteases, and E-64, a cysteine protease inhibitor, further ensure that TMPRSS11F substrates are not degraded by these enzyme classes, indirectly enhancing TMPRSS11F proteolytic action.
Additionally, compounds like Pepstatin A, AEBSF, and Phosphoramidon, which inhibit aspartic, serine, and metalloproteases respectively, serve to enhance TMPRSS11F function by maintaining higher levels of intact substrates for TMPRSS11F to process. Bestatin and Sivelestat specifically target aminopeptidase and neutrophil elastase, preventing the diminishment of peptides that could be potential substrates for TMPRSS11F, consequently promoting its activity. Through these various inhibitory mechanisms, these chemical activators collectively support the enhancement of TMPRSS11F's proteolytic function by ensuring a more favorable substrate environment, directly influencing TMPRSS11F's ability to cleave and activate its specific target proteins.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Benzamidine | 618-39-3 | sc-233933 | 10 g | $292.00 | 1 | |
A reversible protease inhibitor that enhances the activity of TMPRSS11F by inhibiting competitive serine proteases, allowing TMPRSS11F to have increased substrate availability. | ||||||
Camostat mesylate | 59721-29-8 | sc-203867 sc-203867A sc-203867B sc-203867C sc-203867D sc-203867E | 10 mg 50 mg 500 mg 1 g 10 g 100 g | $43.00 $183.00 $312.00 $624.00 $2081.00 $4474.00 | 5 | |
A serine protease inhibitor that can increase TMPRSS11F activity by reducing the activity of competing serine proteases, leading to greater availability of TMPRSS11F's substrates. | ||||||
Nafamostat mesylate | 82956-11-4 | sc-201307 sc-201307A | 10 mg 50 mg | $82.00 $306.00 | 4 | |
A broad-spectrum serine protease inhibitor that, through the reduction of competing protease activities, could indirectly enhance TMPRSS11F activity by increasing the interaction with its specific substrates. | ||||||
Gabexate mesylate | 56974-61-9 | sc-215066 | 5 mg | $100.00 | ||
A synthetic serine protease inhibitor that may enhance TMPRSS11F activity by preventing the degradation of its substrates, thus potentially increasing TMPRSS11F-mediated proteolysis. | ||||||
Aprotinin | 9087-70-1 | sc-3595 sc-3595A sc-3595B | 10 mg 100 mg 1 g | $112.00 $408.00 $3000.00 | 51 | |
A potent serine protease inhibitor that can enhance TMPRSS11F functionality by protecting potential substrates from degradation by other proteases. | ||||||
Leupeptin hemisulfate | 103476-89-7 | sc-295358 sc-295358A sc-295358D sc-295358E sc-295358B sc-295358C | 5 mg 25 mg 50 mg 100 mg 500 mg 10 mg | $73.00 $148.00 $316.00 $499.00 $1427.00 $101.00 | 19 | |
A reversible inhibitor of serine and cysteine proteases that may increase TMPRSS11F activity by preserving its substrates from enzymatic breakdown. | ||||||
E-64 | 66701-25-5 | sc-201276 sc-201276A sc-201276B | 5 mg 25 mg 250 mg | $281.00 $947.00 $1574.00 | 14 | |
An irreversible cysteine protease inhibitor that could support TMPRSS11F activation by reducing competition for substrates that are shared among various proteases. | ||||||
AEBSF hydrochloride | 30827-99-7 | sc-202041 sc-202041A sc-202041B sc-202041C sc-202041D sc-202041E | 50 mg 100 mg 5 g 10 g 25 g 100 g | $65.00 $122.00 $428.00 $851.00 $1873.00 $4994.00 | 33 | |
A serine protease inhibitor that can increase TMPRSS11F activity by reducing the proteolytic degradation of substrates that TMPRSS11F could potentially act upon. | ||||||
Phosphoramidon | 119942-99-3 | sc-201283 sc-201283A | 5 mg 25 mg | $199.00 $632.00 | 8 | |
A metalloprotease inhibitor that may enhance TMPRSS11F activity by preventing substrate cleavage by competing metalloproteases, thus indirectly increasing substrate availability for TMPRSS11F. | ||||||
Bestatin | 58970-76-6 | sc-202975 | 10 mg | $131.00 | 19 | |
An aminopeptidase inhibitor that may indirectly enhance TMPRSS11F activity by preserving peptide substrates from aminopeptidase degradation, thus allowing increased access for TMPRSS11F. | ||||||