TMEM87A Inhibitors
TMEM87A inhibitors pertain to a specialized group of compounds designed to selectively interact with and inhibit the function of the transmembrane protein 87A (TMEM87A). TMEM87A is an integral membrane protein that is encoded by the TMEM87A gene in humans. This protein belongs to a broader category of transmembrane proteins, which play critical roles in various cellular processes due to their positioning within the cell membrane, acting as gatekeepers and communicators for the cell's internal and external environments. Inhibitors targeting TMEM87A are the result of targeted research endeavors focused on understanding the molecular functions and mechanisms of action of this particular protein.
These inhibitors are characterized by their ability to bind to TMEM87A with specificity, a trait that is achieved through the careful design of the inhibitor's molecular structure to ensure compatibility with the protein's binding sites. The interaction between TMEM87A and its inhibitors typically involves the occupation of the active or allosteric sites on the protein, which in turn modulates the protein's activity and can affect the protein's natural role in the cell. The development and study of TMEM87A inhibitors draw from a multidisciplinary approach, incorporating principles from organic chemistry, molecular biology, and computational modeling to optimize the inhibitors' specificity and binding affinity. The precise molecular interactions are often elucidated through techniques like X-ray crystallography, NMR spectroscopy, and other high-resolution structural determination methods that can reveal the inhibitor's conformation within the binding pocket of TMEM87A.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
A glycosylation inhibitor that prevents N-linked glycosylation in the ER. TMEM87A, as a transmembrane protein, requires proper glycosylation for its stability and function. Inhibition of this post-translational modification can lead to misfolding and degradation of TMEM87A. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
A fungal metabolite that disrupts ER to Golgi trafficking. TMEM87A, as a transmembrane protein, relies on this trafficking for its proper localization and function. By disrupting this process, Brefeldin A can prevent the correct placement and functioning of TMEM87A. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
A proteasome inhibitor that can lead to the accumulation of misfolded proteins, triggering ER-associated degradation (ERAD). This can indirectly affect TMEM87A by overwhelming the degradation machinery, potentially targeting TMEM87A for degradation if misfolded. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $41.00 $84.00 $275.00 | 127 | |
An inhibitor of eukaryotic protein synthesis, which can indirectly lead to decreased levels of TMEM87A by preventing its synthesis. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $155.00 $525.00 | ||
A polyether ionophore that alters Golgi apparatus function. It can affect the glycosylation and trafficking of transmembrane proteins like TMEM87A, potentially leading to its functional inhibition. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
A lysosomotropic agent known to inhibit lysosomal enzymes. By increasing lysosomal pH, it can affect the degradation pathway of proteins, including transmembrane proteins like TMEM87A, leading to potential inhibition of its function. | ||||||
GW4869 | 6823-69-4 | sc-218578 sc-218578A | 5 mg 25 mg | $203.00 $611.00 | 24 | |
An inhibitor of sphingomyelinase, which can affect lipid rafts and membrane microdomains. Since TMEM87A is a transmembrane protein, alteration in lipid raft composition may impact its function or localization. | ||||||
Filipin III | 480-49-9 | sc-205323 sc-205323A | 500 µg 1 mg | $118.00 $148.00 | 26 | |
A polyene macrolide that binds to sterols and disrupts lipid raft microdomains. This can affect the localization and function of transmembrane proteins such as TMEM87A. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $89.00 | 44 | |
A small molecule that inhibits dynamin, which is involved in clathrin-mediated endocytosis. This can prevent the internalization and recycling of transmembrane proteins like TMEM87A, affecting its surface expression and function. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
A tyrosine kinase inhibitor that may also affect the phosphorylation state of transmembrane proteins such as TMEM87A, potentially leading to altered signaling and functional inhibition. | ||||||