TMEM87A Activators
TMEM87A activators belong to a class of chemicals that interact with a protein known as Transmembrane Protein 87A (TMEM87A). TMEM87A is an integral membrane protein, which means it is embedded within the lipid bilayer of cells and has one or more segments that span the membrane. As such, it is involved in various cellular processes that require interaction with the cellular environment or signal transduction across the membrane. TMEM87A activators specifically bind to or alter the activity of this protein, which can lead to a cascade of intracellular events. The exact mechanisms through which these activators exert their effects can be diverse, ranging from inducing conformational changes in the protein structure to affecting its interaction with other cellular components.
Chemically, TMEM87A activators can be a heterogeneous group, possibly encompassing a range of small molecules, peptides, or other biologically active compounds. The specificity and affinity of these activators for TMEM87A can vary significantly, influenced by their molecular structures and the presence of functional groups that facilitate effective interaction with the protein target. In terms of chemical properties, TMEM87A activators must possess the necessary characteristics to cross the cellular membrane to reach their site of action, or otherwise, must interact with the extracellular domain of TMEM87A. The structure-activity relationship (SAR) is a critical aspect in the study of these activators, as it defines how the chemical structure of a compound relates to its ability to activate TMEM87A. This relationship is key to understanding the molecular basis of their interaction with the protein and the resulting biochemical consequences.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin, a diterpene, activates adenylyl cyclase thereby increasing the levels of cAMP. Elevated cAMP can enhance TMEM87A function by stimulating protein kinase A (PKA), which may lead to phosphorylation events that activate TMEM87A. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA directly activates protein kinase C (PKC), which is involved in multiple signaling pathways. PKC activation can lead to downstream effects that enhance the activity of TMEM87A through phosphorylation or by altering the cellular environment. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, which can activate calcium-dependent protein kinases. These kinases may then phosphorylate and enhance the activity of TMEM87A. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a synthetic catecholamine that acts as an agonist for beta-adrenergic receptors, leading to increased intracellular cAMP levels. This cAMP accumulation can indirectly enhance TMEM87A activity via PKA-mediated pathways. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram is a selective phosphodiesterase-4 inhibitor, preventing the breakdown of cAMP. The resulting higher cAMP levels can promote PKA activation, which may subsequently enhance the functional activity of TMEM87A. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG acts as a modulator of various protein kinases and phosphatases. Through its action, EGCG could enhance TMEM87A activity by altering the phosphorylation state of proteins involved in TMEM87A's signaling pathway. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases, leading to increased levels of cAMP and cGMP, which can enhance TMEM87A activity indirectly by activating PKA or PKG and influencing their downstream effectors. | ||||||
Ouabain-d3 (Major) | sc-478417 | 1 mg | $516.00 | |||
Ouabain is a cardiac glycoside that inhibits the Na+/K+-ATPase pump, leading to increased intracellular calcium levels. This increase can activate calcium-dependent signaling pathways, potentially enhancing the activity of TMEM87A. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
ZnCl2 can act as a zinc ion donor, influencing various cellular processes including enzyme activation and metalloprotein signaling. Zinc may indirectly enhance TMEM87A activity through modulation of these processes. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
8-Bromo-cAMP is a cell-permeable cAMP analog that activates PKA. By activating PKA, 8-Bromo-cAMP may enhance the activity of TMEM87A through phosphorylation of associated proteins or alteration of the cellular environment for TMEM87A function. | ||||||