Date published: 2026-4-1

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TMEM41A Activators

TMEM41A activators represent a distinct group of chemical agents that target and modulate the activity of the transmembrane protein 41A (TMEM41A), a component of cellular membranes that has garnered attention in the scientific community for its role in cellular processes. These activators are characterized by their ability to influence the function of TMEM41A, potentially affecting various aspects of cell biology such as membrane dynamics, lipid metabolism, and intracellular trafficking. The chemical nature of TMEM41A activators is diverse, encompassing a range of molecules from small organics to larger, more complex structures. Their mode of action can vary significantly, with some directly interacting with the TMEM41A protein to alter its conformation and activity, while others may indirectly modulate its function through effects on associated cellular pathways or regulatory mechanisms.

The study and characterization of TMEM41A activators involve intricate research methodologies that span biochemistry, molecular biology, and chemical biology. Scientists delve into the molecular interactions between these activators and the TMEM41A protein, aiming to unravel the underlying mechanisms that drive their modulatory effects. This includes detailed investigations into the binding sites, structural changes induced upon activator binding, and the subsequent consequences for TMEM41A's role in cellular processes. Such research not only sheds light on the fundamental aspects of TMEM41A function but also contributes to a broader understanding of membrane biology and the complex networks that regulate cellular homeostasis. By elucidating the characteristics and mechanisms of TMEM41A activators, researchers aim to enhance our comprehension of cellular mechanisms, offering insights into the intricate dance of molecular interactions that sustain cellular life.

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Items 1 to 10 of 11 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Metformin

657-24-9sc-507370
10 mg
$79.00
2
(0)

This biguanide may activate AMP-activated protein kinase (AMPK) which is involved in cellular energy homeostasis and could theoretically upregulate genes related to lipid metabolism.

Pioglitazone

111025-46-8sc-202289
sc-202289A
1 mg
5 mg
$55.00
$125.00
13
(1)

As a PPAR-gamma agonist, it may modulate transcription of genes involved in lipid metabolism, potentially influencing TMEM41A expression.

GW501516

317318-70-0sc-202642
sc-202642A
1 mg
5 mg
$82.00
$179.00
28
(3)

This PPAR-delta agonist might enhance the expression of genes associated with fatty acid oxidation, which could include TMEM41A.

Rosiglitazone

122320-73-4sc-202795
sc-202795A
sc-202795C
sc-202795D
sc-202795B
25 mg
100 mg
500 mg
1 g
5 g
$120.00
$326.00
$634.00
$947.00
$1259.00
38
(1)

Another PPAR-gamma agonist that could hypothetically alter the transcription of genes involved in lipid processing.

AICAR

2627-69-2sc-200659
sc-200659A
sc-200659B
50 mg
250 mg
1 g
$65.00
$280.00
$400.00
48
(2)

Activates AMPK and could mimic cellular energy deficit states, potentially influencing the expression of metabolic genes.

Curcumin

458-37-7sc-200509
sc-200509A
sc-200509B
sc-200509C
sc-200509D
sc-200509F
sc-200509E
1 g
5 g
25 g
100 g
250 g
1 kg
2.5 kg
$37.00
$69.00
$109.00
$218.00
$239.00
$879.00
$1968.00
47
(1)

A compound that may affect various signaling pathways and modulate gene expression through its interaction with transcription factors.

Bisphenol A

80-05-7sc-391751
sc-391751A
100 mg
10 g
$300.00
$490.00
5
(0)

Known to interact with estrogen receptors and could induce gene expression changes through receptor-mediated pathways.

D,L-Sulforaphane

4478-93-7sc-207495A
sc-207495B
sc-207495C
sc-207495
sc-207495E
sc-207495D
5 mg
10 mg
25 mg
1 g
10 g
250 mg
$153.00
$292.00
$489.00
$1325.00
$8465.00
$933.00
22
(1)

May activate the Nrf2 pathway, leading to the induction of genes involved in oxidative stress response, which could coincidentally affect TMEM41A.

WY 14643

50892-23-4sc-203314
50 mg
$136.00
7
(1)

As an agonist of PPAR-alpha, it could influence the expression of genes involved in lipid metabolism.

Fenofibrate

49562-28-9sc-204751
5 g
$41.00
9
(1)

Another PPAR-alpha agonist that may enhance the expression of genes related to fatty acid oxidation.