TMEM38B Activators
TMEM38B activators are a class of chemical compounds that have garnered significant attention in the realm of cellular biology and molecular research. These activators are specifically designed to modulate the activity of TMEM38B, a transmembrane protein that plays a crucial role in regulating calcium ion transport within cells. TMEM38B, also known as TRIC-B, is a member of the trimeric intracellular cation channels (TRIC) family. These channels are primarily found in the endoplasmic reticulum (ER) and the sarcoplasmic reticulum (SR) of muscle cells, where they facilitate the controlled release of calcium ions from these intracellular stores.
TMEM38B activators work by interacting with the TMEM38B protein, promoting its activation and thereby enhancing the efflux of calcium ions from the ER and SR into the cytoplasm. This modulation of calcium ion transport is of fundamental importance in various cellular processes, including muscle contraction, neuronal signaling, and intracellular signaling cascades. By fine-tuning the activity of TMEM38B, these activators offer researchers a valuable tool to investigate the physiological and pathological mechanisms associated with calcium ion homeostasis within cells.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ryanodine | 15662-33-6 | sc-201523 sc-201523A | 1 mg 5 mg | $219.00 $765.00 | 19 | |
Ryanodine binds to ryanodine receptors causing the release of calcium from intracellular stores, thereby indirectly enhancing TRIC-B's role in calcium homeostasis. | ||||||
Dantrolene | 7261-97-4 | sc-500165 | 25 mg | $350.00 | 7 | |
Dantrolene inhibits ryanodine receptors, reducing calcium leakage and thus indirectly supporting TRIC-B's function in stabilizing intracellular calcium concentrations. | ||||||
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $27.00 $52.00 | 37 | |
2-APB is an inhibitor of IP3 receptors and also modulates store-operated calcium entry, which can indirectly affect the activity of TRIC-B by influencing calcium signaling pathways. | ||||||
Ruthenium red | 11103-72-3 | sc-202328 sc-202328A | 500 mg 1 g | $184.00 $245.00 | 13 | |
Ruthenium Red blocks calcium channels including ryanodine receptors, which can indirectly facilitate TRIC-B's regulatory role in intracellular calcium handling. | ||||||
SK&F 96365 | 130495-35-1 | sc-201475 sc-201475B sc-201475A sc-201475C | 5 mg 10 mg 25 mg 50 mg | $101.00 $155.00 $389.00 $643.00 | 2 | |
SKF-96365 inhibits receptor-mediated calcium entry, potentially enhancing TRIC-B's function in maintaining cellular calcium homeostasis by modulation of calcium signaling pathways. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin specifically inhibits the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA), leading to a rise in cytosolic calcium levels, which indirectly affects TRIC-B's modulation of calcium homeostasis. | ||||||
Cyclopiazonic Acid | 18172-33-3 | sc-201510 sc-201510A | 10 mg 50 mg | $173.00 $612.00 | 3 | |
Cyclopiazonic Acid is an inhibitor of SERCA, causing an increase in cytosolic calcium that may indirectly enhance the functional activity of TRIC-B in regulating calcium balance. | ||||||
CRAC Channel Inhibitor, BTP2 | 223499-30-7 | sc-221441 | 5 mg | $185.00 | 9 | |
BTP2 is an inhibitor of store-operated calcium entry channels, which could support the function of TRIC-B by modulating intracellular calcium signaling pathways. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is a calcium ionophore that increases intracellular calcium concentration, potentially enhancing TRIC-B's role in intracellular calcium regulation. | ||||||
TMB-8 • HCl | 53464-72-5 | sc-3522 sc-3522A | 10 mg 50 mg | $42.00 $126.00 | 10 | |
TMB-8 is an inhibitor of intracellular calcium release, which may support TRIC-B's function by influencing the intracellular calcium signaling pathways. | ||||||