TMEM29 Inhibitors
Inhibitors that affect TMEM29 function operate through a multitude of modes, impacting several cellular processes. Certain inhibitors act on protein kinases, which play a vital role in the phosphorylation events that regulate protein function within cells. As the activity of TMEM29 is dependent on precise phosphorylation, disruption of these enzymes can lead to a lack of necessary post-translational modifications, impairing TMEM29 activity. There are also molecules that interfere with the acidification process within endosomal structures, a step critical for the proper sorting and operation of TMEM29, as it affects the protein's optimal localization which is essential for its function.
In addition, TMEM29's activity can be influenced by agents that alter the lipid composition of cellular membranes, potentially disrupting the protein's anchoring and its associated activities. Compounds that affect the dynamics of the cytoskeleton and membrane trafficking pathways also play a role, as these are important for the correct placement and integration of TMEM29 within the cell membrane. Furthermore, the inhibition of key signaling pathways that govern cellular responses could also indirectly modulate the function of TMEM29. The manipulation of protein folding processes, particularly in the endoplasmic reticulum, could lead to misfolded TMEM29 proteins, reducing their stability and function. Inhibitors that block endocytic pathways could further impact the distribution and surface presence of TMEM29. Finally, the targeting of enzymes involved in lipid signaling and membrane dynamics can have profound effects on the localization and function of TMEM29, emphasizing the intricacy of cellular mechanisms that regulate its activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
An indolocarbazole that inhibits protein kinases. TMEM29 activity can be regulated by phosphorylation; thus, staurosporine indirectly inhibits TMEM29 by preventing its phosphorylation. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $96.00 $250.00 $750.00 $1428.00 | 280 | |
Inhibits V-ATPases, disrupting endosomal acidification. This can lead to the dysregulation of endosomal sorting and indirectly inhibit TMEM29's localization and function. | ||||||
Wiskostatin | 253449-04-6 | sc-204399 sc-204399A sc-204399B sc-204399C | 1 mg 5 mg 25 mg 50 mg | $48.00 $122.00 $432.00 $812.00 | 4 | |
A cell-permeable, reversible inhibitor of N-WASP (neural Wiskott-Aldrich syndrome protein). By inhibiting N-WASP, it indirectly affects actin polymerization and membrane trafficking pathways that could involve TMEM29. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
An isoflavone that inhibits tyrosine kinases. By blocking tyrosine phosphorylation, it may indirectly inhibit TMEM29's interactions or modifications that depend on these phosphorylation events. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $87.00 | 44 | |
A small molecule that inhibits dynamin and thus clathrin-mediated endocytosis. TMEM29's function and membrane localization could be affected by this inhibition, leading to indirect suppression of its activity. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
A synthetic compound that inhibits MEK, which is upstream of ERK in the MAPK pathway. By inhibiting this pathway, PD 98059 may indirectly affect TMEM29's role in signaling or trafficking. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $169.00 $299.00 | 66 | |
An N-glycosylation inhibitor that disrupts protein folding in the ER, possibly affecting TMEM29's folding and stability, thus indirectly inhibiting its proper function. | ||||||
U 18666A | 3039-71-2 | sc-203306 sc-203306A | 10 mg 50 mg | $140.00 $500.00 | 2 | |
A cholesterol transport inhibitor impacting intracellular cholesterol distribution. This may affect lipid raft composition and indirectly disrupt TMEM29's localization or function. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $145.00 $442.00 | 64 | |
An inhibitor of actin polymerization, impeding cytoskeletal dynamics. Since TMEM29 is a membrane protein, its trafficking and surface expression could be indirectly inhibited by cytochalasin D. | ||||||
GW4869 | 6823-69-4 | sc-218578 sc-218578A | 5 mg 25 mg | $199.00 $599.00 | 24 | |
A neutral sphingomyelinase inhibitor, affecting ceramide biosynthesis and possibly TMEM29's associated signaling pathways that involve sphingolipids. | ||||||