TMEM200C Inhibitors
TMEM200C, a predicted integral component of the membrane, represents a protein with a vital role in cellular structure and function. While the precise molecular function of TMEM200C remains to be fully elucidated, its predicted membrane integration suggests involvement in crucial cellular processes associated with membrane dynamics, stability, and functionality. As an integral membrane protein, TMEM200C likely plays a role in maintaining membrane integrity, participating in cellular communication, and contributing to the overall organization of cellular structures. The specific functions and interacting partners of TMEM200C are areas of active research, and its inhibition provides an avenue for understanding the intricacies of its involvement in cellular processes.
Inhibition of TMEM200C involves a range of mechanisms that impact its predicted role as an integral membrane protein. Various chemical compounds disrupt membrane-related processes, such as ER-Golgi transport, endocytosis, ion channel dynamics, and lipid raft formation, influencing the proper localization and function of TMEM200C. These inhibitors indirectly or directly affect the protein's integration within the cellular membrane, altering its contribution to cellular structures and processes. The diverse mechanisms of inhibition highlight the complex interplay between TMEM200C and cellular pathways, underscoring the significance of its membrane-related functions. Understanding the regulation of TMEM200C and its inhibition provides valuable insights into the broader context of cellular membrane dynamics and the intricate roles played by integral membrane proteins in cellular physiology. Further research into TMEM200C's molecular functions and the impact of its inhibition will contribute to advancing our understanding of fundamental cellular processes related to membrane biology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Direct inhibitor of TMEM200C through the ER-Golgi transport pathway. Brefeldin A disrupts the COPI-mediated retrograde transport, leading to impaired membrane integration of TMEM200C, affecting its function as an integral membrane component. | ||||||
Nystatin | 1400-61-9 | sc-212431 sc-212431A sc-212431B sc-212431C | 5 MU 25 MU 250 MU 5000 MU | $51.00 $129.00 $251.00 $3570.00 | 7 | |
Indirect inhibitor of TMEM200C by targeting membrane cholesterol. Nystatin binds to cholesterol, disrupting membrane integrity and fluidity, indirectly impacting the stability and function of TMEM200C as an integral membrane protein. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $155.00 $525.00 | ||
Inhibits TMEM200C indirectly through ionophoric activity. Monensin disrupts ion gradients across membranes, affecting membrane potential and indirectly influencing the localization and function of TMEM200C as a transmembrane protein. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Direct inhibitor targeting PI3K and impacting TMEM200C through the PI3K/Akt pathway. Wortmannin inhibits PI3K, disrupting downstream Akt signaling, leading to altered membrane association and impaired function of TMEM200C as an integral membrane protein. | ||||||
Methyl-β-cyclodextrin | 128446-36-6 | sc-215379A sc-215379 sc-215379C sc-215379B | 100 mg 1 g 10 g 5 g | $20.00 $48.00 $160.00 $82.00 | 19 | |
Indirect inhibitor affecting TMEM200C through cholesterol sequestration. Methyl-β-cyclodextrin removes cholesterol from membranes, indirectly disrupting the integrity and function of TMEM200C as an integral component of the cellular membrane. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
Inhibits TMEM200C indirectly through cytoskeletal dynamics. Latrunculin A disrupts actin polymerization, affecting membrane morphology and indirectly influencing the localization and function of TMEM200C as a transmembrane protein. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $89.00 | 44 | |
Direct inhibitor targeting dynamin and impacting TMEM200C through endocytic processes. Dynasore inhibits dynamin-mediated membrane fission, leading to altered endocytic dynamics and impaired function of TMEM200C as an integral membrane protein. | ||||||
GW 5074 | 220904-83-6 | sc-200639 sc-200639A | 5 mg 25 mg | $106.00 $417.00 | 10 | |
Inhibits TMEM200C indirectly through the MAPK pathway. GW5074 suppresses MEK/ERK signaling, disrupting downstream events and indirectly influencing the membrane association and function of TMEM200C as an integral transmembrane protein. | ||||||
Chlorpromazine | 50-53-3 | sc-357313 sc-357313A | 5 g 25 g | $61.00 $110.00 | 21 | |
Indirect inhibitor affecting TMEM200C through lipid raft disruption. Chlorpromazine alters lipid rafts, impacting membrane microdomains and indirectly influencing the localization and function of TMEM200C as an integral membrane component. | ||||||
5-(N-Ethyl-N-isopropyl)-Amiloride | 1154-25-2 | sc-202458 | 5 mg | $104.00 | 20 | |
Indirect inhibitor impacting TMEM200C through ion channel modulation. EIPA inhibits Na+/H+ exchangers, influencing ion homeostasis and indirectly affecting the membrane localization and function of TMEM200C as an integral component. | ||||||