TMEM186 Activators
TMEM186 Activators consist of diverse chemical agents that can potentiate the functional activities of TMEM186 through various cellular and molecular pathways. Forskolin and 8-Br-cAMP, through the elevation of intracellular cAMP, activate PKA, which could potentially enhance TMEM186 activity by phosphorylation, given TMEM186 is a substrate for PKA. Similarly, Rolipram inhibits PDE4, leading to increased cAMP and subsequent PKA activation that can result in the phosphorylation of TMEM186. Ionomycin and A23187 act as calcium ionophores, boosting intracellular calcium levels, which may trigger the activation of calcium-dependent kinases capable of phosphorylating TMEM186. PMA, as a PKC activator, could also phosphorylate TMEM186, assuming it is a PKC substrate, leading to increased protein activity.
Further influencing TMEM186 activity are chemicals that affect various signaling pathways and cellular states. Spermidine, which induces autophagy, may increase TMEM186 function within this pathway. Epigallocatechin gallate, a kinase inhibitor, could shift signaling dynamics to favor TMEM186 activation if it is normally inhibited by these kinases. Sildenafil, by inhibiting PDE5 and increasing cGMP levels, could potentiate TMEM186 activity through cGMP-dependent protein kinases if TMEM186 is a substrate.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing intracellular cAMP levels. Elevated cAMP enhances PKA activity, which could phosphorylate TMEM186 if it is a PKA substrate, thus increasing its activity. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
8-Bromo-cAMP is a cAMP analog that activates PKA. PKA activation could lead to the phosphorylation and activation of TMEM186 if it is a PKA substrate. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium concentrations, potentially activating calcium-dependent kinases that could phosphorylate and activate TMEM186. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC), which might phosphorylate and thereby enhance the activity of TMEM186 if it is a PKC substrate. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $57.00 $607.00 $176.00 | ||
Spermidine can induce autophagy, a process TMEM186 may be involved in. Enhanced autophagy could lead to an increased functional activity of TMEM186 within this context. | ||||||
SB-216763 | 280744-09-4 | sc-200646 sc-200646A | 1 mg 5 mg | $71.00 $202.00 | 18 | |
SB216763 is a GSK-3β inhibitor that may stabilize proteins through reduced proteasomal degradation. If TMEM186 is regulated by GSK-3β, its activity could be enhanced by this compound. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is another calcium ionophore that increases intracellular calcium, potentially activating kinases that phosphorylate and activate TMEM186. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG inhibits multiple kinases, which could shift signaling equilibria to favor the activation of TMEM186 if its activation is suppressed by these kinases. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram inhibits PDE4, raising cAMP levels and potentially activating PKA. This activation could lead to phosphorylation and activation of TMEM186 if it is a PKA substrate. | ||||||