TMEM182 inhibitors represent a class of chemical compounds that specifically target and inhibit the activity of the transmembrane protein 182 (TMEM182). TMEM182 is a protein encoded by the TMEM182 gene, and it is characterized by its presence in cellular membranes, where it plays a role in various intracellular processes. The inhibitors of TMEM182 are designed to modulate the function of this protein by binding to it and altering its conformational state or preventing its normal interaction with other molecules in the cell. These inhibitors are typically small organic compounds that can interact with specific domains of the TMEM182 protein, thereby altering its structural and functional properties. The exact mechanisms of inhibition may vary depending on the structure of the inhibitor and its binding affinity for the protein.
Inhibitors of TMEM182 can be useful tools in molecular biology research, as they provide insight into the biological pathways and cellular processes in which TMEM182 is involved. By selectively inhibiting the activity of TMEM182, researchers can better understand the protein's role in regulating various cellular functions, such as signaling pathways, protein transport, or membrane dynamics. These inhibitors can be studied in different experimental models to explore the consequences of TMEM182 inhibition on cellular processes, which can include changes in protein-protein interactions, alterations in membrane permeability, or shifts in intracellular signaling. Understanding the biochemical properties and molecular interactions of TMEM182 inhibitors can contribute to advancing knowledge in cellular biology and biochemistry.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
A ROCK inhibitor, potentially affecting cytoskeletal dynamics and membrane-associated proteins like TMEM182. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
An mTOR inhibitor, possibly impacting signaling pathways related to TMEM182 function. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
An inhibitor of protein transport from the endoplasmic reticulum to the Golgi, affecting membrane protein trafficking. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A PI3K inhibitor, could influence signaling pathways involving TMEM182. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $62.00 $90.00 $299.00 $475.00 $1015.00 $2099.00 | 69 | |
An immunosuppressant that inhibits calcineurin, potentially affecting signaling pathways linked to TMEM182. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
A PI3K inhibitor that could impact TMEM182-related pathways. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
A specific inhibitor of MEK, which may indirectly influence TMEM182 activity. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
A non-selective protein kinase inhibitor, potentially affecting TMEM182-related signaling. | ||||||
Chlorpromazine | 50-53-3 | sc-357313 sc-357313A | 5 g 25 g | $60.00 $108.00 | 21 | |
A psychotropic agent affecting various neurotransmitters, also influences membrane protein trafficking. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $169.00 $299.00 | 66 | |
An inhibitor of N-linked glycosylation, affecting the maturation and trafficking of membrane proteins like TMEM182. | ||||||