TMEM182 Activators
TMEM182 activators are chemicals that target the transmembrane protein 182 (TMEM182), which is an integral component of cellular membranes. TMEM182 is a relatively less characterized protein that is embedded within the lipid bilayer of cells and is thought to play a role in various cellular functions, possibly including intracellular signaling, cellular structure maintenance, or the regulation of other membrane proteins. Activators in this class have been developed with the goal of modulating the protein's activity. These activators may interact with TMEM182 by binding to it directly or by affecting the membrane environment in a way that alters the protein's conformation and, consequently, its activity. The interaction between TMEM182 and its activators may induce a range of biochemical responses within the cell, depending on the structure and function of the protein.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin directly stimulates adenylyl cyclase, leading to an increase in intracellular cAMP levels. Elevated cAMP activates PKA, which can then phosphorylate target proteins, including TMEM182. Through this phosphorylation, TMEM182's activity as a transmembrane protein could be enhanced, potentially affecting its role in membrane signaling or transport. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a diacylglycerol analogue that activates protein kinase C (PKC). Activation of PKC leads to the phosphorylation of proteins involved in various signaling pathways. TMEM182, being a transmembrane protein, could have its function enhanced by PKC-mediated phosphorylation, impacting its role in cellular signaling or membrane dynamics. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels. The rise in calcium can activate calcium-dependent signaling pathways, potentially leading to the activation of TMEM182 if it plays a role in calcium-mediated signaling or transport across the membrane. | ||||||
8-Bromoadenosine 3′,5′-cyclic monophosphate | 23583-48-4 | sc-217493B sc-217493 sc-217493A sc-217493C sc-217493D | 25 mg 50 mg 100 mg 250 mg 500 mg | $108.00 $169.00 $295.00 $561.00 $835.00 | 2 | |
8-Bromo-cAMP is a cell-permeable cAMP analog that activates cAMP-dependent pathways by mimicking cAMP. This activation could enhance TMEM182's function by phosphorylation through PKA or by other cAMP-dependent mechanisms, assuming TMEM182 is regulated by cAMP signaling. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
S1P is a bioactive lipid that activates S1P receptors, triggering downstream signaling that can lead to the activation of several protein kinases. If TMEM182 is involved in or affected by S1P receptor signaling pathways, its activity could be enhanced as part of the receptor's downstream effects. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is a polyphenol from green tea with kinase inhibitory activity. By inhibiting certain protein kinases, it may reduce negative regulatory influences on TMEM182, indirectly enhancing its activity, especially if TMEM182 is part of a signaling pathway normally regulated by these kinases. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a specific inhibitor of PI3K. By inhibiting PI3K, it can alter downstream signaling pathways, such as the AKT pathway. If TMEM182's activity is linked to the PI3K/AKT pathway, inhibition by LY294002 could lead to a compensatory mechanism in the cell that indirectly enhances the activity of TMEM182. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $57.00 $191.00 $302.00 $450.00 $1800.00 $3570.00 $10710.00 | 4 | |
NAD+ is a coenzyme in redox reactions and a substrate for sirtuins and ADP-ribose transferases, which are involved in various cellular processes including DNA repair and gene expression. If TMEM182 is regulated by sirtuin activity or ADP-ribosylation, an increase in NAD+ levels could enhance its functional activity. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid acts as a ligand for nuclear hormone receptors and influences gene expression. If TMEM182 is regulated by gene expression changes induced by retinoic acid signaling, then retinoic acid could enhance its activity through increased protein levels or by initiating signaling cascades that TMEM182 is a part of. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $31.00 $61.00 $95.00 | 28 | |
List of TMEM182 Activators | ||||||