TMEM16H Activators
TMEM16H activators predominantly function by influencing intracellular calcium levels or pathways that result in the modification of these levels. These compounds, upon influencing these pathways, can enhance the functional activity of TMEM16H. For instance, Forskolin, an activator of adenylyl cyclase, and IBMX can increase intracellular cAMP levels. The elevated cAMP levels can activate protein kinase A, which in turn can phosphorylate and activate TMEM16H. Similarly, UTP and ATP can activate P2Y receptors, leading to the production of IP3 and DAG through the phospholipase C pathway, indirectly enhancing the activity of TMEM16H.
Moreover, other compounds like Ouabain, Thapsigargin, A23187, Genistein, Glyburide, Verapamil, BAPTA-AM, and Nifedipine can also influence intracellular calcium levels, leading to the enhanced functional activity of TMEM16H. For example, Ouabain inhibits the sodium-potassium ATPase pump, which can lead to an increase in intracellular calcium levels, enhancing the activity of TMEM16H. Thapsigargin causes an increase in cytosolic calcium levels, enhancing the activity of TMEM16H.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is an activator of adenylyl cyclase, an enzyme that increases levels of cyclic adenosine monophosphate (cAMP) in cells. The elevated cAMP levels can activate protein kinase A (PKA), which in turn can phosphorylate and activate TMEM16H. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a nonspecific inhibitor of phosphodiesterases, enzymes that degrade cAMP. By inhibiting these enzymes, IBMX can increase intracellular cAMP levels, indirectly leading to the activation of TMEM16H through the PKA pathway. | ||||||
Uridine-5′-triphosphate, Trisodium Salt | 19817-92-6 | sc-301964 sc-301964A | 50 mg 1 g | $88.00 $120.00 | 2 | |
UTP activates P2Y receptors that are G protein-coupled receptors. These receptors can activate phospholipase C, leading to the production of inositol trisphosphate (IP3) and diacylglycerol (DAG), which can enhance the activity of TMEM16H. | ||||||
ADP | 58-64-0 | sc-507362 | 5 g | $54.00 | ||
ATP can also activate P2Y receptors, leading to the production of IP3 and DAG through the phospholipase C pathway, indirectly enhancing the activity of TMEM16H. | ||||||
Ouabain-d3 (Major) | sc-478417 | 1 mg | $516.00 | |||
Ouabain inhibits the sodium-potassium ATPase pump, which can lead to an increase in intracellular calcium levels. The elevated calcium levels can enhance the activity of TMEM16H. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin inhibits the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA), causing an increase in cytosolic calcium levels. This increase can enhance the activity of TMEM16H. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is a calcium ionophore that can increase intracellular calcium concentration, which can enhance the activity of TMEM16H. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein inhibits protein tyrosine kinases, which can lead to alterations in intracellular signaling pathways, potentially enhancing the activity of TMEM16H. | ||||||
Glyburide (Glibenclamide) | 10238-21-8 | sc-200982 sc-200982A sc-200982D sc-200982B sc-200982C | 1 g 5 g 25 g 100 g 500 g | $46.00 $61.00 $117.00 $173.00 $530.00 | 36 | |
Glyburide inhibits ATP-sensitive K+ channels, leading to membrane depolarization and the opening of voltage-gated calcium channels, enhancing the activity of TMEM16H. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $374.00 | ||
Verapamil is a calcium channel blocker that can modify intracellular calcium levels, indirectly leading to the activation of TMEM16H. | ||||||