TMEM168 Inhibitors
TMEM168 Inhibitors are chemicals aiming at either the direct modulation of the protein's function or the indirect manipulation of the broader cellular processes it might be involved in. Given that TMEM168's detailed roles and pathways are not fully elucidated, many of these inhibitors, such as Chlorpromazine or Wortmannin, are chosen based on their potential to influence a wide array of transmembrane proteins or associated pathways.
For instance, compounds like Dynasore, targeting endocytosis, provide a route to potentially influence the trafficking and function of transmembrane proteins like TMEM168. On a more direct level, agents such as Nystatin and Filipin III affect membrane integrity and properties, a key determinant of the function and behavior of transmembrane proteins. Furthermore, chemicals like Methyl-β-cyclodextrin highlight the intricate relationship between membrane cholesterol content and protein function. U18666A, by inducing cholesterol accumulation in specific cellular compartments, can impact the dynamics of transmembrane proteins.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Chlorpromazine | 50-53-3 | sc-357313 sc-357313A | 5 g 25 g | $60.00 $108.00 | 21 | |
Interacts with the lipid bilayer, altering membrane dynamics and potentially disrupting TMEM168's proper function. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
By inhibiting PI3K, it can disrupt intracellular signaling that may regulate TMEM168's function or expression. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $87.00 | 44 | |
Prevents the GTPase activity of dynamin, affecting endocytosis. This might interfere with TMEM168's internalization or recycling. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
As a tyrosine kinase inhibitor, it can affect cellular pathways that might modulate TMEM168's phosphorylation or signaling functions. | ||||||
Amiloride • HCl | 2016-88-8 | sc-3578 sc-3578A | 25 mg 100 mg | $22.00 $56.00 | 6 | |
By blocking sodium channels, it can change ion concentrations, indirectly affecting the electrochemical gradient which TMEM168 might rely on. | ||||||
Manumycin A | 52665-74-4 | sc-200857 sc-200857A | 1 mg 5 mg | $215.00 $622.00 | 5 | |
By inhibiting Ras farnesyltransferase, it can disrupt Ras signaling pathways that might regulate TMEM168's function. | ||||||
5-(N-Ethyl-N-isopropyl)-Amiloride | 1154-25-2 | sc-202458 | 5 mg | $102.00 | 20 | |
By inhibiting macropinocytosis, it may prevent the uptake of extracellular molecules that regulate TMEM168. | ||||||
Nystatin | 1400-61-9 | sc-212431 sc-212431A sc-212431B sc-212431C | 5 MU 25 MU 250 MU 5000 MU | $50.00 $126.00 $246.00 $3500.00 | 7 | |
Binds to cholesterol in the cell membrane, altering its fluidity and potentially affecting TMEM168's mobility or interactions. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $152.00 $515.00 | ||
Alters ion gradients across membranes, potentially affecting TMEM168's ion sensitivity or related functions. | ||||||
Filipin III | 480-49-9 | sc-205323 sc-205323A | 500 µg 1 mg | $116.00 $145.00 | 26 | |
Binds to sterols in the membrane, potentially disrupting lipid rafts or regions where TMEM168 operates optimally. | ||||||