TMEM165 Activators
TMEM165 activators represent a specialized chemical class renowned for their ability to modulate the activity of TMEM165, a protein encoded by the TMEM165 gene. TMEM165, also known as Transmembrane protein 165, is a transmembrane protein localized primarily in the Golgi apparatus. Although its precise function is not fully elucidated, TMEM165 is believed to play a crucial role in ion transport and ion homeostasis across Golgi membranes. Activators targeting TMEM165 likely exert their effects by influencing its ion channel activity, protein-protein interactions, or membrane localization. These activators play a pivotal role in unraveling the biological functions of TMEM165 and its contributions to cellular physiology.
Structurally, TMEM165 activators may display a diverse array of chemical scaffolds, reflecting the complexity required for effective engagement with the target protein. These molecules may harbor specific binding motifs or functional groups facilitating their interaction with TMEM165, thereby modulating its activity with precision. Understanding the structural and biochemical properties of TMEM165 activators is essential for unraveling the molecular mechanisms underlying the functions of this protein and its involvement in cellular processes. Further exploration of the pharmacological characteristics and biological significance of TMEM165 activators holds promise for advancing our understanding of cellular physiology and may offer insights into novel strategies for manipulating ion transport and membrane dynamics in various biological contexts.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
May upregulate TMEM165 as part of the unfolded protein response (UPR) by inducing ER stress and affecting glycosylation. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Could increase TMEM165 expression by causing ER calcium depletion, triggering the UPR and potentially affecting glycosylation. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Might enhance TMEM165 expression by disrupting ER-Golgi transport, inducing stress that impacts glycosylation processes. | ||||||
Sodium phenylbutyrate | 1716-12-7 | sc-200652 sc-200652A sc-200652B sc-200652C sc-200652D | 1 g 10 g 100 g 1 kg 10 kg | $77.00 $166.00 $622.00 $5004.00 $32783.00 | 43 | |
As a chemical chaperone, might upregulate TMEM165 by alleviating ER stress and assisting in protein folding and glycosylation. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
Could induce TMEM165 expression by inhibiting the proteasome, leading to accumulation of misfolded proteins and ER stress. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $63.00 $182.00 | 8 | |
As a hormone, might modulate TMEM165 expression through estrogen receptor pathways, potentially influencing ER and Golgi functions. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
May influence TMEM165 expression through its role in cellular differentiation and development, possibly affecting glycosylation. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Could increase TMEM165 expression by elevating cAMP levels, affecting various signaling pathways including those related to the UPR. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
Might modulate TMEM165 expression through its roles in cellular metabolism and possibly ER function, given vitamin D's involvement in gene regulation. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Could modulate TMEM165 expression through its effects on cellular antioxidant systems and potentially on glycosylation. | ||||||