TMEM163 Activators
TMEM163 activators are a diverse set of chemicals that can influence the activity or expression of the TMEM163 protein, either directly or through the modulation of interconnected cellular pathways. One notable representative is Phorbol 12-myristate 13-acetate (PMA), which activates protein kinase C. This can impact various cellular pathways, leading to changes in the activity or localization of transmembrane proteins like TMEM163. Forskolin, another activator, enhances the activity of adenylate cyclase, thereby increasing intracellular cAMP levels. Elevated cAMP can, in turn, regulate the trafficking or expression of transmembrane proteins, including TMEM163.
Further expanding the list, Ionomycin, a calcium ionophore, raises intracellular calcium levels, providing another mode of influencing the behavior of calcium-responsive transmembrane proteins. U0126, which inhibits MEK1/2, offers another route of influence by modulating the ERK pathway, while MG-132 stabilizes proteins by inhibiting proteasomal degradation. This stabilization can affect the lifecycle of transmembrane proteins, such as TMEM163. Other agents like Wortmannin and Chloroquine exert their effects by modulating intracellular signaling and endosomal pH respectively, with potential consequences on the function or expression of TMEM163. Brefeldin A, Rapamycin, and Latrunculin A provide further examples, impacting protein transport, mTOR signaling, and actin polymerization, respectively.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
An activator of protein kinase C which can influence various cellular pathways, potentially affecting the activity of transmembrane proteins like TMEM163. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
An activator of adenylate cyclase, increasing cAMP levels, which can regulate transmembrane protein trafficking or expression. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
A calcium ionophore that increases intracellular calcium levels, potentially influencing the function of transmembrane proteins. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
A proteasome inhibitor which can stabilize proteins, indirectly affecting the degradation of transmembrane proteins. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A calcium ionophore, which can alter intracellular calcium levels and potentially affect the activity of calcium-responsive transmembrane proteins. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
An inhibitor of protein phosphatases 1 and 2A, which can modulate protein phosphorylation states, potentially influencing transmembrane protein activity. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Known to influence endosomal pH and can impact the trafficking of transmembrane proteins. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Disrupts protein transport from the endoplasmic reticulum to the Golgi apparatus, potentially impacting the localization and function of transmembrane proteins. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
Disrupts actin polymerization and might impact the dynamics of transmembrane proteins that associate with the cytoskeleton. | ||||||