TMEM147 Inhibitors
TMEM147 Inhibitors include a diverse set of chemicals aimed at targeting various cellular pathways with which TMEM147 is presumed to interact. For instance, Cyclopamine and IWP-2 are inhibitors that target the Hedgehog and Wnt pathways, respectively. By inhibiting these pathways, these chemicals serve to impede the function of TMEM147 if it acts downstream or in concert with these pathways. Similarly, chemicals like LY294002 and Wortmannin are PI3K inhibitors that target cellular survival and growth mechanisms, intersecting with TMEM147 roles.
Other chemicals like U0126 and PD98059 act as inhibitors for the MEK/ERK signaling pathway. This inhibition can disrupt any role TMEM147 may have in this pathway, especially relating to cellular growth and differentiation. Moreover, compounds like Rapamycin and SB431542 focus on the mTOR and TGF-β pathways, inhibiting TMEM147's presumed functions in cellular growth and differentiation. The collective aim of these inhibitors is to act on a particular set of signaling pathways to influence a broader range of cellular activities that may include the functions of TMEM147.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
BML-275 | 866405-64-3 | sc-200689 sc-200689A | 5 mg 25 mg | $94.00 $348.00 | 69 | |
Dorsomorphin inhibits BMP signaling, which can influence cellular differentiation. Its action can restrain the presumed roles of TMEM147 in cellular differentiation. | ||||||
Cyclopamine | 4449-51-8 | sc-200929 sc-200929A | 1 mg 5 mg | $92.00 $204.00 | 19 | |
Cyclopamine specifically inhibits the Hedgehog signaling pathway. TMEM147, if associated with this pathway, will see inhibited function. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 inhibits PI3K and can potentially regulate TMEM147 involvement in cellular survival pathways. | ||||||
IWP-2 | 686770-61-6 | sc-252928 sc-252928A | 5 mg 25 mg | $94.00 $286.00 | 27 | |
IWP-2 inhibits Wnt production, affecting downstream TMEM147 activities related to Wnt signaling. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is an MEK inhibitor that can disrupt pathways in which TMEM147 may function, such as ERK signaling. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, affecting cellular growth and possibly TMEM147's roles in these processes. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
SB431542 inhibits TGF-β signaling. If TMEM147 is implicated, its activity can be hindered. | ||||||
GW 5074 | 220904-83-6 | sc-200639 sc-200639A | 5 mg 25 mg | $106.00 $417.00 | 10 | |
GW5074 is a Raf-1 kinase inhibitor affecting downstream MAPK activation. If TMEM147 is regulated by MAPK signaling, its function will be inhibited. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP2 inhibits Src family kinases, affecting various cellular functions that TMEM147 might be involved in. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a JNK inhibitor affecting stress response pathways, where TMEM147 might play a role. | ||||||