TMEM114 Activators
TMEM114 activators would target pathways and processes that indirectly modulate the activity of this transmembrane protein. For instance, compounds such as Forskolin could be employed to increase intracellular levels of cAMP, which in turn activates PKA (protein kinase A). PKA could potentially phosphorylate TMEM114 or change the protein's activity by altering the local cellular environment. Similarly, ionophores like Ionomycin might be used to raise intracellular calcium levels, which could activate calcium-dependent signaling pathways that modulate TMEM114 activity. These pathways could influence the protein's conformation or interactions with other cellular components, leading to an enhancement of its functionality.
Another strategy could involve the use of growth factors or cytokines to initiate broader signaling cascades that have downstream effects on TMEM114. For instance, Epidermal Growth Factor (EGF) could activate the EGFR pathway, which might indirectly enhance TMEM114 functionality as part of the broader modulation of cellular processes. Additionally, lipid signaling molecules such as Sphingosine-1-phosphate (S1P) could affect the actin cytoskeleton and cell adhesion dynamics, potentially influencing TMEM114's distribution or activity within the membrane. Modulators of oxidative stress, like Hydrogen Peroxide (H2O2), could also be considered, as they can influence several signaling pathways through their role as secondary messengers, potentially affecting the activity of TMEM114.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylyl cyclase, leading to increased levels of cyclic AMP (cAMP) in cells. TMEM114, being a transmembrane protein, could be influenced by the cAMP-dependent protein kinase A (PKA) signaling pathway. This elevation in cAMP and subsequent PKA activation can enhance TMEM114 functionality by phosphorylation or by changing the cellular environment in a way that favors TMEM114's activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC). PKC activation can lead to the phosphorylation of proteins and alteration of their function. TMEM114 could be indirectly influenced by PKC through phosphorylation or changes in the cellular microenvironment that promote TMEM114's activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore which increases intracellular calcium levels. Elevated calcium can activate calcium-dependent signaling pathways, potentially affecting TMEM114's activity through calcium-sensitive protein interactions or modifications. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $153.00 $1224.00 $12239.00 | 82 | |
Insulin receptor signaling can lead to various intracellular signaling cascades, including the PI3K/Akt pathway. Activation of this pathway may indirectly enhance TMEM114 function by altering membrane trafficking or protein-protein interactions that could affect TMEM114. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $30.00 $60.00 $93.00 | 27 | |
H2O2 serves as a signaling molecule that can modulate the activity of various protein kinases and phosphatases. TMEM114 could be indirectly affected by redox signaling pathways influenced by H2O2, potentially enhancing its activity through oxidative modifications. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
S1P is a bioactive lipid that activates sphingosine-1-phosphate receptors (S1PRs) and can lead to actin cytoskeleton rearrangements. These cellular changes can indirectly enhance the functionality of TMEM114 by altering its localization or interaction with other membrane proteins. | ||||||
(±)-S-Nitroso-N-acetylpenicillamine | 79032-48-7 | sc-200319B sc-200319 sc-200319A | 10 mg 20 mg 100 mg | $73.00 $112.00 $367.00 | 18 | |
Nitric oxide can activate guanylyl cyclase, increasing levels of cGMP. TMEM114 may be indirectly influenced by cGMP-dependent protein kinases or signaling pathways, which could enhance its activity through phosphorylation events or changes in cellular signaling. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid modulates gene expression via retinoic acid receptors. While it does not directly interact with TMEM114, the alteration of gene expression patterns could indirectly enhance TMEM114 function by affecting proteins that interact with or regulate TMEM114. | ||||||
Bisphenol A | 80-05-7 | sc-391751 sc-391751A | 100 mg 10 g | $300.00 $490.00 | 5 | |
Bisphenol A can interact with estrogen receptors and initiate estrogen receptor signaling. This pathway can lead to numerous cellular effects that could indirectly enhance TMEM114 functionality through alterations in cellular signaling and membrane dynamics. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin has been shown to modulate various signaling pathways, including those involving NF-κB. Such modulation potentially affects TMEM114 indirectly by altering the cellular context in which TMEM114 operates, thereby enhancing its activity. | ||||||