TMEM107 Activators

Forskolin and dibutyryl-cAMP elevate cAMP levels, thereby activating protein kinase A, which can phosphorylate and modulate TMEM107. Ionomycin, by increasing intracellular calcium, triggers a cascade of calcium-dependent kinases that may target TMEM107 for activation. Phorbol esters such as PMA activate protein kinase C, which is known to phosphorylate a spectrum of proteins, including TMEM107. The PI3K/Akt pathway, a crucial signal transduction route, is influenced by LY294002, which inhibits PI3K, potentially leading to alterations in TMEM107's activity. Similarly, the MAPK/ERK pathway, which is central to cell growth and differentiation, is targeted by compounds like PD98059 and U0126, which specifically inhibit MEK, thereby affecting TMEM107 activity indirectly. Compounds such as SB431542 and SP600125 exert their effects through the inhibition of TGF-β receptor kinases and JNK, respectively, signaling pathways that are capable of intersecting with those regulating TMEM107.

Rapamycin, with its mTOR inhibitory activity, impacts cellular growth and metabolism, processes which can cascade down to TMEM107 regulation. Y-27632's inhibition of ROCK affects the cytoskeletal dynamics, which can influence TMEM107's cellular localization and function. The activation of the Wnt pathway by Wnt Agonist 1 demonstrates the broad signaling interactions that can indirectly modulate the activity of TMEM107 within cellular growth and differentiation processes.