TMED4 Activators
TMED4 activators encompass a variety of chemical compounds that indirectly bolster the functional activity of TMED4 through distinct signaling pathways. Compounds like Forskolin, 8-Bromo-cAMP, and Dibutyryl-cAMP enhance TMED4's role by elevating cAMP levels, leading to protein kinase A (PKA) activation, which in turn may promote the phosphorylation and functional enhancement of TMED4 in vesicular transport. Similarly, the action of Ionomycin and A23187, as calcium ionophores, raises intracellular calcium levels, potentially activating calcium-dependent proteins that could interact and co-operatively enhance TMED4's transport capabilities. The modulation of PKC by Phorbol 12-myristate 13-acetate (PMA) and the inhibition of protein kinases by Epigallocatechin gallate (EGCG) also serve to potentially augment TMED4's efficiency in vesicle formation and trafficking.
Further, Genistein's inhibition of tyrosine kinases may reduce competitive signaling, indirectly favoring TMED4's functional activities. PI3K inhibitors such as LY294002 and Wortmannin can lead to a reconfiguration of phosphorylation patterns that may include TMED4, thus potentially enhancing its role in vesicular trafficking. The MEK1/2 inhibitor U0126 could similarly induce a shift in cellular signaling, which might inadvertently increase TMED4 activity due to compensatory cellular responses. Wortmannin's inhibition of PI3K may also result in a favorable alteration of the signaling milieu for TMED4, promoting its involvement in the trafficking process.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing intracellular cAMP levels. Elevated cAMP activates PKA, which can phosphorylate proteins including TMED4, potentially enhancing its role in vesicular trafficking processes. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
8-Bromo-cAMP is a cAMP analog that activates PKA. Activated PKA may increase the phosphorylation status of TMED4, leading to an enhanced functional role in the secretory pathway as a cargo receptor. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels. Elevated calcium may activate calcium-binding proteins that interact with TMED4, facilitating its transport functions. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a PKC activator that can modulate intracellular signaling. Activated PKC may phosphorylate proteins that associate with TMED4, indirectly enhancing its trafficking capabilities. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl-cAMP, a cAMP analog, bypasses adenylyl cyclase to raise intracellular cAMP levels, leading to PKA activation. This activation could increase TMED4 functional activity by enhancing its role in vesicular transport. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is a calcium ionophore facilitating Ca2+ influx, which could activate signaling pathways that phosphorylate or change the localization of TMED4, potentially increasing its efficiency in protein trafficking. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin inhibits the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA), leading to increased cytosolic calcium. This may activate pathways that enhance TMED4's role in ER-Golgi transport. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG inhibits several protein kinases and might enhance TMED4 function by altering phosphorylation states of proteins that regulate vesicular trafficking, leading to more efficient TMED4-mediated transport. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a tyrosine kinase inhibitor that may upregulate TMED4's activity by reducing competition from tyrosine kinase signaling, possibly allowing TMED4 to more effectively participate in its transport and signaling roles. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor, which may lead to altered phosphorylation patterns in the cell, including those of TMED4, potentially resulting in enhanced vesicular trafficking mediated by TMED4. | ||||||