TM9SF3 Inhibitors
TM9SF3 inhibitors belong to a category of chemical compounds specifically designed to interact with the transmembrane 9 superfamily protein member 3 (TM9SF3), a protein that has been identified as playing a significant role in various cellular processes. The exact function of TM9SF3 is still a subject of research, but it has been found to be involved in the regulation of cellular adhesion, ion transport, and possibly in the autophagy process, which is the natural, regulated mechanism of the cell that removes unnecessary or dysfunctional components. TM9SF3 inhibitors are crafted through a meticulous process of molecular design and synthesis to ensure they have a high affinity for the TM9SF3 protein and can effectively bind to it, thus influencing its activity within the cell.
The development of TM9SF3 inhibitors requires a comprehensive understanding of the protein's structure and the molecular interactions that govern its function. Researchers utilize a variety of techniques, including computational modeling, crystallography, and mutagenesis studies, to map the active sites and conformational dynamics of TM9SF3. This information is pivotal in the design of molecules that can either block or modulate the activity of the protein by fitting into its active or allosteric sites. The inhibitors are typically characterized by their selectivity and potency, which are critical parameters in defining their efficacy in modulating the function of TM9SF3. Precision in the molecular interaction is crucial, as it determines the inhibitor's capacity to bind to the protein without affecting other proteins with similar structures. This specificity is achieved through iterative cycles of design, synthesis, and testing, which refine the chemical structure of the inhibitors for optimal interaction with TM9SF3.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
A potent inhibitor of phosphoinositide 3-kinases (PI3K). Given that TM9SF3 is involved in cellular adhesion and migration processes, inhibition of PI3K can alter the actin cytoskeleton organization, thereby indirectly reducing TM9SF3-mediated cellular adhesion. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Another PI3K inhibitor that prevents the phosphorylation of AKT, leading to reduced cell survival signals. Since TM9SF3 function is associated with cellular survival, the inhibition of this pathway might indirectly decrease TM9SF3's role in supporting cell viability. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
A selective inhibitor of mitogen-activated protein kinase kinase (MEK), which is part of the MAPK/ERK pathway. By inhibiting this pathway, cellular processes related to proliferation that might indirectly involve TM9SF3 are affected. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
An inhibitor of c-Jun N-terminal kinase (JNK), which has roles in stress response and apoptosis. Modulation of this pathway can alter cellular responses in which TM9SF3 may be implicated, particularly in the context of stress signaling. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
A selective inhibitor of p38 MAPK, involved in inflammatory responses and stress. TM9SF3 may play a role in these cellular responses, and inhibition of p38 MAPK may indirectly affect TM9SF3's functional activity within these contexts. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $458.00 | 61 | |
A calcium chelator that can reduce intracellular calcium levels. As calcium signaling may influence TM9SF3's role in cellular processes, decreasing calcium concentrations could indirectly impair TM9SF3-mediated activities. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
A selective inhibitor of Rho-associated protein kinase (ROCK), which is involved in regulating the cytoskeleton. This can lead to changes in cell shape and motility that may indirectly involve TM9SF3's functional role in these processes. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $105.00 $299.00 $474.00 | 15 | |
A protein kinase C (PKC) inhibitor. PKC is involved in various cellular functions, and its inhibition can disrupt processes where TM9SF3 might play an indirect role, potentially diminishing TM9SF3 activity. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
An inhibitor of the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA), leading to an increase in cytosolic calcium levels and potentially affecting TM9SF3's role in calcium-dependent signaling pathways. | ||||||
BML-275 | 866405-64-3 | sc-200689 sc-200689A | 5 mg 25 mg | $96.00 $355.00 | 69 | |
An inhibitor of AMP-activated protein kinase (AMPK), which is a sensor of cellular energy status. Inhibiting AMPK could affect TM9SF3's involvement in energy-dependent cellular processes. | ||||||