TM9SF3 Activators
TM9SF3 activators are a class of chemical compounds that interact with the transmembrane 9 superfamily protein member 3 (TM9SF3), a protein that is embedded within the cellular membrane. TM9SF3 is known to be involved in various cellular processes, including the maintenance of cellular structure and function, as well as the regulation of certain signaling pathways that are critical for cellular homeostasis. Activators of TM9SF3 influence the activity of this protein, resulting in modulation of its functional behavior. These activators can bind to TM9SF3 and induce conformational changes that either enhance or mimic the protein's natural activity, thus affecting the downstream processes in which TM9SF3 is involved.
The biochemical mechanisms through which TM9SF3 activators exert their influence involve complex interactions at the molecular level. These activators typically have specific binding sites on the TM9SF3 protein where they attach, leading to alterations in the protein's structure. This binding can affect the protein's interaction with other cellular components, potentially altering intracellular signaling pathways. The precise molecular structure of TM9SF3 activators can vary widely, encompassing a range of small molecules with diverse chemical properties and structures. Researchers studying these compounds focus on understanding the pharmacodynamics-how the activators affect TM9SF3 function-and pharmacokinetics, which pertain to the behavior of these compounds within a biological system, including their absorption, distribution, metabolism, and excretion. Despite the absence of discussion on their use in medicine, TM9SF3 activators continue to be a focal point for basic research due to their role in fundamental cellular functions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylyl cyclase, leading to an increase in cyclic AMP (cAMP) levels in cells. Elevated cAMP activates protein kinase A (PKA), which can phosphorylate target proteins. This phosphorylation can enhance the functional activity of TM9SF3 by promoting its localization to the plasma membrane where it facilitates endocytosis. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is a potent antioxidant that can modulate signal transduction pathways. Specifically, it inhibits certain protein kinases and protects cells from oxidative stress, which can indirectly lead to the activation of TM9SF3 by preserving its structure and function under conditions that might otherwise lead to protein damage. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a diacylglycerol (DAG) analog that activates protein kinase C (PKC). PKC activation can modulate various signaling pathways, including those that involve TM9SF3, by altering the phosphorylation state of proteins that interact with or regulate TM9SF3, thereby enhancing its activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium concentrations. Elevated calcium levels can activate calcium-dependent signaling pathways, leading to the activation of proteins that may interact with TM9SF3, thus potentially enhancing its activity. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
S1P binds to its receptors and activates G-protein-coupled receptor (GPCR) signaling cascades, which can lead to actin cytoskeleton reorganization. This reorganization may enhance the endocytic function of TM9SF3 by affecting the membrane dynamics. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a phosphoinositide 3-kinase (PI3K) inhibitor. By inhibiting PI3K, it can modulate downstream Akt signaling, leading to potential alterations in the pathways that regulate TM9SF3, thereby indirectly enhancing its functional activity. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAPK inhibitor. By inhibiting p38 MAPK, it can shift cellular responses towards alternative pathways that may involve TM9SF3, potentially enhancing its activity in processes such as endocytosis or cell adhesion. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is an inhibitor of mitogen-activated protein kinase kinase (MEK), which is upstream of ERK in the MAPK pathway. Inhibition of this pathway can lead to the activation of alternative signaling routes that may involve TM9SF3, enhancing its functional activity. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000B sc-24000C | 10 µg 100 µg 500 µg 1 mg | $160.00 $750.00 $1400.00 $3000.00 | 59 | |
Calyculin A is an inhibitor of protein phosphatases PP1 and PP2A. This inhibition can lead to increased phosphorylation levels of proteins within the cell, which may enhance the activity of TM9SF3 through indirect phosphorylation-dependent mechanisms. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a protein synthesis inhibitor that activates stress-activated protein kinases (SAPKs). Activation of SAPKs can lead to the modulation of signaling pathways that influence TM9SF3 activity, thereby indirectly enhancing its function. | ||||||